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  • Bài trích
  • Ký hiệu PL/XG: 615
    Nhan đề: Nghiên cứu định lượng đồng thời curdion và germacron trong viên nang mềm ngải trắng /
DDC 615
Tác giả CN Nguyễn, Đức Hạnh
Nhan đề Nghiên cứu định lượng đồng thời curdion và germacron trong viên nang mềm ngải trắng / Nguyễn Đức Hạnh, Lê Thị Ngọc Anh, Võ Thanh Hóa
Mô tả vật lý 6 tr.
Tóm tắt Considering curdion and germacron as the main bioactive compounds of the Curcuma aromatica Salish, an HPLC method was developed for quantitative determination of them in the Curcuma aromatica (CA) soft gelatin capsules based on the available reported methods for curdion and germacron determination in C. aromatic extracts. The method was established as: Culumn - Perfecsil 100 ODS-3 (250 mm x 4.6 mm; 5 pm); Detector - UV (214 nm); Column temperature - 30°C; Mobile phase — acetonitrile and water, gradient mode; Flow rate - 1 ml/min. The ratios of acetonitrile were 42%; 55% and 49% at 0-15 min, 18-23 min and 30-52 min. As for specificity and suitability, the proposed method proved well meeting the conventional requirements. The linearity was desirably good for both curdion (y = 14922x. R2 = 1) and germacron (y = 66868x, R2 = 1). The % RSD values of inter-day precision of curdion and germacron were 1.13% and 1.21%, respectively. The recovery percentages of curdion and germacron were 99.96 — 103.55% and 97.42 — 102. 03%, respective This proposed HPLC method met the requirements of validation and showed useful for establishing the quality standard of CA soft capsules.
Từ khóa tự do Dược liệu
Từ khóa tự do HPLC
Từ khóa tự do Cao đặc ngải trắng
Từ khóa tự do Curcuma aromatica
Từ khóa tự do Curdion
Từ khóa tự do Germacron
Từ khóa tự do Soft capsule
Tác giả(bs) CN Lê, Thị Ngọc Anh
Tác giả(bs) CN Võ, Thanh Hóa
Nguồn trích Tạp chí Dược học 2020Tr. 38-43 Số: 03
000 00000nab#a2200000ui#4500
00120745
0029
0048F649868-A5D5-4C4D-929D-CCADCB7E44B5
005202004221123
008081223s vm| vie
0091 0
039|y20200422112326|zngantk
082 |a615
100 |aNguyễn, Đức Hạnh
245 |aNghiên cứu định lượng đồng thời curdion và germacron trong viên nang mềm ngải trắng / |cNguyễn Đức Hạnh, Lê Thị Ngọc Anh, Võ Thanh Hóa
300 |a6 tr.
520 |aConsidering curdion and germacron as the main bioactive compounds of the Curcuma aromatica Salish, an HPLC method was developed for quantitative determination of them in the Curcuma aromatica (CA) soft gelatin capsules based on the available reported methods for curdion and germacron determination in C. aromatic extracts. The method was established as: Culumn - Perfecsil 100 ODS-3 (250 mm x 4.6 mm; 5 pm); Detector - UV (214 nm); Column temperature - 30°C; Mobile phase — acetonitrile and water, gradient mode; Flow rate - 1 ml/min. The ratios of acetonitrile were 42%; 55% and 49% at 0-15 min, 18-23 min and 30-52 min. As for specificity and suitability, the proposed method proved well meeting the conventional requirements. The linearity was desirably good for both curdion (y = 14922x. R2 = 1) and germacron (y = 66868x, R2 = 1). The % RSD values of inter-day precision of curdion and germacron were 1.13% and 1.21%, respectively. The recovery percentages of curdion and germacron were 99.96 — 103.55% and 97.42 — 102. 03%, respective This proposed HPLC method met the requirements of validation and showed useful for establishing the quality standard of CA soft capsules.
653 |aDược liệu
653 |aHPLC
653 |aCao đặc ngải trắng
653 |aCurcuma aromatica
653 |aCurdion
653 |aGermacron
653 |aSoft capsule
700 |aLê, Thị Ngọc Anh
700 |aVõ, Thanh Hóa
773 |tTạp chí Dược học |d2020|gTr. 38-43|i03
890|c1|a0|b0|d27
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