thông tin biểu ghi
  • Sách tham khảo
  • Ký hiệu PL/XG: 615.19 I195
    Nhan đề: Identification and determination of impurities in drugs /

ISBN 0444828990
DDC 615.19
Nhan đề Identification and determination of impurities in drugs / [Edited by] S Görög
Lần xuất bản 1st ed.
Thông tin xuất bản Amsterdam ; New York : Elsevier,2000
Mô tả vật lý 773 pages. : illustrations
Tùng thư Progress in pharmaceutical and biomedical analysis, v. 4.
Tóm tắt Impurity profiling is the common name of a group of analytical activities, the aim of which is the detection, identification/structure elucidation and quantitative determination of organic and inorganic impurities, as well as residual solvents in bulk drugs and pharmaceutical formulations. Since this is the best way to characterise the quality and stability of bulk drugs and pharmaceutical formulations, this is the core activity in modern drug analysis. Due to the very rapid development of the analytical methodologies available for this purpose and the similarly rapid increase of the demands as regards the purity of drugs it is an important task to give a summary of the problems and the various possibilities offered by modern analytical chemistry for their solution. That is the aim of this book. The book is methodology-oriented. In the first chapter some important aspects of the background of impurity-related analytical studies (toxicological, pharmacopoeial aspects, the characterisation of the sources of impurities and the role of impurity profiling in various fields of drug research, production and therapeutic use) are summarised. Chapter two deals with related organic impurities, the strategies for impurity profiling, the use of chromatographic and related separation methods, spectroscopic, and hyphenated techniques. The subject of the third chapter is the identification and determination of residual solvents. The determination of inorganic impurities is discussed in chapter four. The special problems of degradation products as impurities are dealt with in chapter five. A separate chapter has been compiled to deal with one of the most up-to-date problems in contemporary pharmaceutical analysis, the estimation of enantiomeric purity of chiral drugs. Chapter seven is devoted to various approaches to solve the problem of polymorphic modifications as impurities. Since in the broader sense of the word the microbiological purity of drugs and drug products also belongs to this circle, the most important information from this field is summarised in chapter eight. After the mainly methodology-oriented chapters, the final one concentrates on four groups of drugs (peptides, biotechnological products, antibiotics and steroids) in order to demonstrate the use of the methods described earlier.
Thuật ngữ chủ đề Drugs-Analysis.
Thuật ngữ chủ đề Contamination (Technology)
Thuật ngữ chủ đề Drug adulteration.
Khoa Khoa Dược
Tác giả(bs) CN Görög, S.
Địa chỉ Thư Viện Đại học Nguyễn Tất Thành
000 00000nam#a2200000u##4500
00127558
0022
0044594C05B-E817-44D5-9245-2AF50569C903
005202103221244
008210319s2000 ne eng
0091 0
020 |a0444828990
039|a20210322124410|btainguyendientu|y20210319170225|znghiepvu
040 |aNTT
041 |aeng
044 |ane
082 |a615.19|bI195|223
245 |aIdentification and determination of impurities in drugs / |c[Edited by] S Görög
250 |a1st ed.
260 |aAmsterdam ; New York : |bElsevier,|c2000
300 |a773 pages. : |billustrations
490 |aProgress in pharmaceutical and biomedical analysis, v. 4.
520 |aImpurity profiling is the common name of a group of analytical activities, the aim of which is the detection, identification/structure elucidation and quantitative determination of organic and inorganic impurities, as well as residual solvents in bulk drugs and pharmaceutical formulations. Since this is the best way to characterise the quality and stability of bulk drugs and pharmaceutical formulations, this is the core activity in modern drug analysis. Due to the very rapid development of the analytical methodologies available for this purpose and the similarly rapid increase of the demands as regards the purity of drugs it is an important task to give a summary of the problems and the various possibilities offered by modern analytical chemistry for their solution. That is the aim of this book. The book is methodology-oriented. In the first chapter some important aspects of the background of impurity-related analytical studies (toxicological, pharmacopoeial aspects, the characterisation of the sources of impurities and the role of impurity profiling in various fields of drug research, production and therapeutic use) are summarised. Chapter two deals with related organic impurities, the strategies for impurity profiling, the use of chromatographic and related separation methods, spectroscopic, and hyphenated techniques. The subject of the third chapter is the identification and determination of residual solvents. The determination of inorganic impurities is discussed in chapter four. The special problems of degradation products as impurities are dealt with in chapter five. A separate chapter has been compiled to deal with one of the most up-to-date problems in contemporary pharmaceutical analysis, the estimation of enantiomeric purity of chiral drugs. Chapter seven is devoted to various approaches to solve the problem of polymorphic modifications as impurities. Since in the broader sense of the word the microbiological purity of drugs and drug products also belongs to this circle, the most important information from this field is summarised in chapter eight. After the mainly methodology-oriented chapters, the final one concentrates on four groups of drugs (peptides, biotechnological products, antibiotics and steroids) in order to demonstrate the use of the methods described earlier.
541 |aMua
650 |aDrugs|xAnalysis.
650 |aContamination (Technology)
650 |aDrug adulteration.
690 |aKhoa Dược
700 |aGörög, S.|eedited
852 |aThư Viện Đại học Nguyễn Tất Thành
8561|uhttp://elib.ntt.edu.vn/documentdata01/2 tailieuthamkhao/600 congnghe/anhbiasach/27558_identificationanddeterminationofimpuritiesindrugs_k_001thumbimage.jpg
890|c1|a0|b0|d1
Không tìm thấy biểu ghi nào