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ISSN
| 1949-2553 | |
DDC
| 660 | |
Nhan đề
| Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient / Nam Nhut Phan, Chih-Yang Wang, Kuan-Lun Li, Chien-Fu Chen, Chung-Chieh Chiao, Han-Gang Yu, Pung-Ling Huang, Yen-Chang Lin | |
Thông tin xuất bản
| New York : Impact Journals, LLC, 2018 | |
Mô tả vật lý
| 16 p. | |
Tóm tắt
| Breast cancer is a dangerous disease that results in high mortality rates for cancer patients. Many methods have been developed for the treatment and prevention of this disease. Determining the expression patterns of certain target genes in specific subtypes of breast cancer is important for developing new therapies for breast cancer. In the present study, we performed a holistic approach to screening the mRNA expression of six members of the cell division cycle-associated gene family (CDCA) with a focus on breast cancer using the Oncomine and The Cancer Cell Line Encyclopedia (CCLE) databases. Furthermore, Gene Expression-Based Outcome for Breast Cancer Online (GOBO) was also used to deeply mine the expression of each CDCA gene in clinical breast cancer tissue and breast cancer cell lines. Finally, the mRNA expression of the CDCA genes as related to breast cancer patient survival were analyzed using a Kaplan-Meier plot. CDCA3, CDCA5, and CDCA8 mRNA expression levels were significantly higher than the control sample in both clinical tumor sample and cancer cell lines. These highly expressed genes in the tumors of breast cancer patients dramatically reduced patient survival. The interaction network of CDCA3, CDCA5, and CDCA8 with their co-expressed genes also revealed that CDCA3 expression was highly correlated with cell cycle related genes such as CCNB2, CDC20, CDKN3, and CCNB1. CDCA5 expression was correlated with BUB1 and TRIP13, while CDCA8 expression was correlated with BUB1 and CCNB1. Altogether, these findings suggested CDCA3, CDCA5, and CDCA8 could have a high potency as targeted breast cancer therapies. | |
Từ khóa tự do
| Breast cancer | |
Từ khóa tự do
| Bioinformatics | |
Từ khóa tự do
| Prognosis | |
Từ khóa tự do
| Cell cycle division-associated (CDCA) protein | |
Từ khóa tự do
| Cell cycle | |
Khoa
| Khoa Y | |
Khoa
| Khoa Công nghệ sinh học | |
Tác giả(bs) CN
| Phan, Nhut Nam | |
Tác giả(bs) CN
| Li, Kuan-Lun | |
Tác giả(bs) CN
| Wang, Chih-Yang | |
Tác giả(bs) CN
| Lin, Yen-Chang | |
Tác giả(bs) CN
| Huang, Pung-Ling | |
Tác giả(bs) CN
| Chen, Chien-Fu | |
Tác giả(bs) CN
| Chiao, Chung-Chieh | |
Tác giả(bs) CN
| Yu, Han-Gang | |
Nguồn trích
| .
Số: Vol. 9 (2018), P.6977-6992, , | |
Nguồn trích
| Oncotarget. , , | |
Địa chỉ
| Thư Viện Đại học Nguyễn Tất Thành | |
Tệp tin điện tử
| http://doi.org/10.18632/oncotarget.24059 |
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| 245 | |aDistinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient / |cNam Nhut Phan, Chih-Yang Wang, Kuan-Lun Li, Chien-Fu Chen, Chung-Chieh Chiao, Han-Gang Yu, Pung-Ling Huang, Yen-Chang Lin |
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| 260 | |aNew York : |bImpact Journals, LLC, |c2018 |
|---|
| 300 | |a16 p. |
|---|
| 520 | |aBreast cancer is a dangerous disease that results in high mortality rates for cancer patients. Many methods have been developed for the treatment and prevention of this disease. Determining the expression patterns of certain target genes in specific subtypes of breast cancer is important for developing new therapies for breast cancer. In the present study, we performed a holistic approach to screening the mRNA expression of six members of the cell division cycle-associated gene family (CDCA) with a focus on breast cancer using the Oncomine and The Cancer Cell Line Encyclopedia (CCLE) databases. Furthermore, Gene Expression-Based Outcome for Breast Cancer Online (GOBO) was also used to deeply mine the expression of each CDCA gene in clinical breast cancer tissue and breast cancer cell lines. Finally, the mRNA expression of the CDCA genes as related to breast cancer patient survival were analyzed using a Kaplan-Meier plot. CDCA3, CDCA5, and CDCA8 mRNA expression levels were significantly higher than the control sample in both clinical tumor sample and cancer cell lines. These highly expressed genes in the tumors of breast cancer patients dramatically reduced patient survival. The interaction network of CDCA3, CDCA5, and CDCA8 with their co-expressed genes also revealed that CDCA3 expression was highly correlated with cell cycle related genes such as CCNB2, CDC20, CDKN3, and CCNB1. CDCA5 expression was correlated with BUB1 and TRIP13, while CDCA8 expression was correlated with BUB1 and CCNB1. Altogether, these findings suggested CDCA3, CDCA5, and CDCA8 could have a high potency as targeted breast cancer therapies. |
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| 653 | |aBreast cancer |
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| 653 | |aBioinformatics |
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| 653 | |aPrognosis |
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| 653 | |aCell cycle division-associated (CDCA) protein |
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| 653 | |aCell cycle |
|---|
| 690 | |aKhoa Y |
|---|
| 690 | |aKhoa Công nghệ sinh học |
|---|
| 700 | |aPhan, Nhut Nam |
|---|
| 700 | |aLi, Kuan-Lun |
|---|
| 700 | |aWang, Chih-Yang |
|---|
| 700 | |aLin, Yen-Chang |
|---|
| 700 | |aHuang, Pung-Ling |
|---|
| 700 | |aChen, Chien-Fu |
|---|
| 700 | |aChiao, Chung-Chieh |
|---|
| 700 | |aYu, Han-Gang |
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| 773 | |gVol. 9 (2018), P.6977-6992 |
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| 773 | |tOncotarget |
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| 852 | |aThư Viện Đại học Nguyễn Tất Thành |
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| 856 | |uhttp://doi.org/10.18632/oncotarget.24059 |
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| 890 | |c1|a0|b0|d1 |
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