thông tin biểu ghi
  • Bài trích
  • Ký hiệu PL/XG: 615
    Nhan đề: Nghiên cứu bào chế hệ nano chất mang lipid chứa curcumin /

DDC 615
Tác giả CN Dương, Thị Hồng Ánh
Nhan đề Nghiên cứu bào chế hệ nano chất mang lipid chứa curcumin / Dương Thị Hồng Ánh, Phạm Thị Hằng
Tóm tắt As curcumin (a polyphenol in nature, isolated from tumeric Curcuma longa L.) is well-known for its antioxidant and ant-inflammatory activity; yet, its use is more or less limited due to its poor oral bioavailability resuting from its poor water solubilty, poor oral absorption, extensive metabolism in the liver and rapid elimination from the body; to overcome these all, a curcumin-nanostructured lipid carrier system was formulated for oral delivery. Influences of solid lipid (glycerin monostearat and cetylic alcol), liquid lipid (Labrafac PG, Labrafac lipophile and Miglyol® 812), surfactants (Tween 80 and Span 80) and preparation operation on the mean particle size, polydispersity index and in vitro drug release were studied. The obtained curcumin-nanostructured lipid carrier system with glycerin monostearate, Labrafac lipophile, Span 80 and Tween 80 achieved desirably small mean particle size (147.3 ± 16.4 nm) along with polydispersity index (0.404 ± 0.017) and drug release of 40.3% after 8 hrs.
Thuật ngữ chủ đề Nghiên cứu - Kỹ thuật --Việt Nam
Từ khóa tự do Curcumin
Từ khóa tự do Lipid
Từ khóa tự do Nano
Tác giả(bs) CN Phạm, Thị Hằng
Nguồn trích Tạp chí Dược học 2018tr. 59-63 Số: 02
000 00000nab#a2200000ui#4500
00118894
0029
004557034D8-EE43-4549-9433-09450E8BC2AD
005201912131108
008081223s vm| vie
0091 0
039|y20191213110804|zthienvan
082 |a615
100 |aDương, Thị Hồng Ánh
245 |aNghiên cứu bào chế hệ nano chất mang lipid chứa curcumin / |cDương Thị Hồng Ánh, Phạm Thị Hằng
520 |aAs curcumin (a polyphenol in nature, isolated from tumeric Curcuma longa L.) is well-known for its antioxidant and ant-inflammatory activity; yet, its use is more or less limited due to its poor oral bioavailability resuting from its poor water solubilty, poor oral absorption, extensive metabolism in the liver and rapid elimination from the body; to overcome these all, a curcumin-nanostructured lipid carrier system was formulated for oral delivery. Influences of solid lipid (glycerin monostearat and cetylic alcol), liquid lipid (Labrafac PG, Labrafac lipophile and Miglyol® 812), surfactants (Tween 80 and Span 80) and preparation operation on the mean particle size, polydispersity index and in vitro drug release were studied. The obtained curcumin-nanostructured lipid carrier system with glycerin monostearate, Labrafac lipophile, Span 80 and Tween 80 achieved desirably small mean particle size (147.3 ± 16.4 nm) along with polydispersity index (0.404 ± 0.017) and drug release of 40.3% after 8 hrs.
650 |aNghiên cứu - Kỹ thuật |zViệt Nam
653 |aCurcumin
653 |aLipid
653 |aNano
700 |aPhạm, Thị Hằng
773 |tTạp chí Dược học |d2018|gtr. 59-63|i02
890|c1|a0|b0|d3
Không tìm thấy biểu ghi nào