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  • Bài trích
  • Ký hiệu PL/XG: 615
    Nhan đề: Phát hiện tân dược nhóm ức chế Enzym Phosphodiesterase 5 trộn trái phép trong thuốc đông dược và thực phẩm chức năng bằng kỹ thuật vân tay cộng hưởng từ hạt nhân (1H-NMR fingerprint) /
DDC 615
Tác giả CN Đào, Thị Thanh Hiền
Nhan đề Phát hiện tân dược nhóm ức chế Enzym Phosphodiesterase 5 trộn trái phép trong thuốc đông dược và thực phẩm chức năng bằng kỹ thuật vân tay cộng hưởng từ hạt nhân (1H-NMR fingerprint) / Đào Thị Thanh Hiền, Nguyễn Lâm Hồng, Trần Việt Hùng
Tóm tắt 1H-NMR spectroscopy was used for detecting the presence and identification of phosphodiesterase-5 enzyme inhibitors (PDE-5i) medicines (such as sildenafil, tadalafil, vardenafil and their analogues) as frequent adulterants in dietary supplements (DS) or herbal medicines marketed for improving sexual performance, which were claimed to contain only natural compounds, plant extracts and/or vitamins. A follow-up over time of several DSs revealed that manufacturers made illegal changes in the chemical composition of the formulations, adding forbidden ingredients. It is for the first time in Vietnam, 1H NMR was used as a complementary method for detecting DS adulterated with phosphodiesterase-5 enzyme inhibitors (PDE-5i). On practical application, two DSs were analyzed showing to be adulterated with 2 phosphodiesterase-5 enzyme inhibitors (PDE-5i) (tadalafil, vardenafill) and DS M6 was mixed with 2 sildernafil structurally modified analogues. And furthemore, these proved 1H-NMR spectroscopy to be powerful as a first-line method for the detection of adulterated herbal/natural DS, and n the other hand, called for more effective quality control of natural DS.
Thuật ngữ chủ đề Nghiên cứu - Kỹ Thuật --Việt Nam
Từ khóa tự do Enzym Phosphodiesterase
Từ khóa tự do kỹ thuật vân tay
Tác giả(bs) CN Nguyễn, Lâm Hồng
Nguồn trích Tạp chí Dược học 2018tr. 56-61 Số: 03
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039|y20191212141847|zthienvan
082 |a615
100 |aĐào, Thị Thanh Hiền
245 |aPhát hiện tân dược nhóm ức chế Enzym Phosphodiesterase 5 trộn trái phép trong thuốc đông dược và thực phẩm chức năng bằng kỹ thuật vân tay cộng hưởng từ hạt nhân (1H-NMR fingerprint) / |cĐào Thị Thanh Hiền, Nguyễn Lâm Hồng, Trần Việt Hùng
520 |a1H-NMR spectroscopy was used for detecting the presence and identification of phosphodiesterase-5 enzyme inhibitors (PDE-5i) medicines (such as sildenafil, tadalafil, vardenafil and their analogues) as frequent adulterants in dietary supplements (DS) or herbal medicines marketed for improving sexual performance, which were claimed to contain only natural compounds, plant extracts and/or vitamins. A follow-up over time of several DSs revealed that manufacturers made illegal changes in the chemical composition of the formulations, adding forbidden ingredients. It is for the first time in Vietnam, 1H NMR was used as a complementary method for detecting DS adulterated with phosphodiesterase-5 enzyme inhibitors (PDE-5i). On practical application, two DSs were analyzed showing to be adulterated with 2 phosphodiesterase-5 enzyme inhibitors (PDE-5i) (tadalafil, vardenafill) and DS M6 was mixed with 2 sildernafil structurally modified analogues. And furthemore, these proved 1H-NMR spectroscopy to be powerful as a first-line method for the detection of adulterated herbal/natural DS, and n the other hand, called for more effective quality control of natural DS.
650 |aNghiên cứu - Kỹ Thuật |zViệt Nam
653 |aEnzym Phosphodiesterase
653 |akỹ thuật vân tay
700 |aNguyễn, Lâm Hồng
773 |tTạp chí Dược học |d2018|gtr. 56-61|i03
890|c1|a0|b0|d4
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