|
DDC
| 615 | |
Tác giả CN
| Lê, Đình Quang | |
Nhan đề
| Xây dựng công thức màng bao bảo vệ viên nén 2 lớp Amoxicillin và Acid Clavulanic giải phóng kéo dài / Lê Đình Quang, Nguyễn Phương Nhung, Nguyễn Ngọc Chiến, Nguyễn Văn Long | |
Tóm tắt
| A coating film was formulated for 2-layer extended release tablets of amoxicillin and clavulanic acid. The tablets were coated with hydroxypropyl methylcellulose (HPMC) E15, Eudragit EPO [poly(methacrylate-methylmethacrylate)], Eudragit E100, Opadry, and Opadry AMB [poly(vinylalcohol)-based formulation]. HPMC E15 was selected as polymer, and combined with talc, stearic acid, PEG 6000 (20%; 10% and 15%, respectively, calculared on the polymer). The coating weight gain of the obtained tablets was 4%. The film-coating showed good moisture-proof properties with a moisture absorption of 0.41% after 6 hours’ exposition to the ambient humidity of 95%. Chemically, the obtained HPMC coated tablets were stable. The amoxicillin and clavulanic acid contents remained unchanged (105.1 and 102.2%, respectively) after 3 days of storage under natural ambient conditions. | |
Thuật ngữ chủ đề
| Nghiên cứu - kỹ thuật --Việt Nam | |
Từ khóa tự do
| Acid Clavulanic | |
Từ khóa tự do
| Amoxicillin | |
Tác giả(bs) CN
| Nguyễn, Phương Nhung | |
Nguồn trích
| Tạp chí Dược học 2018tr. 14-20
Số: 07 |
| |
000
| 00000nab#a2200000ui#4500 |
|---|
| 001 | 18736 |
|---|
| 002 | 9 |
|---|
| 004 | D696136D-68CB-4318-A8B4-82E7047B009F |
|---|
| 005 | 201912070951 |
|---|
| 008 | 081223s vm| vie |
|---|
| 009 | 1 0 |
|---|
| 039 | |y20191207095108|zthienvan |
|---|
| 082 | |a615 |
|---|
| 100 | |aLê, Đình Quang |
|---|
| 245 | |aXây dựng công thức màng bao bảo vệ viên nén 2 lớp Amoxicillin và Acid Clavulanic giải phóng kéo dài / |cLê Đình Quang, Nguyễn Phương Nhung, Nguyễn Ngọc Chiến, Nguyễn Văn Long |
|---|
| 520 | |aA coating film was formulated for 2-layer extended release tablets of amoxicillin and clavulanic acid. The tablets were coated with hydroxypropyl methylcellulose (HPMC) E15, Eudragit EPO [poly(methacrylate-methylmethacrylate)], Eudragit E100, Opadry, and Opadry AMB [poly(vinylalcohol)-based formulation]. HPMC E15 was selected as polymer, and combined with talc, stearic acid, PEG 6000 (20%; 10% and 15%, respectively, calculared on the polymer). The coating weight gain of the obtained tablets was 4%. The film-coating showed good moisture-proof properties with a moisture absorption of 0.41% after 6 hours’ exposition to the ambient humidity of 95%. Chemically, the obtained HPMC coated tablets were stable. The amoxicillin and clavulanic acid contents remained unchanged (105.1 and 102.2%, respectively) after 3 days of storage under natural ambient conditions. |
|---|
| 650 | |aNghiên cứu - kỹ thuật |zViệt Nam |
|---|
| 653 | |aAcid Clavulanic |
|---|
| 653 | |aAmoxicillin |
|---|
| 700 | |aNguyễn, Phương Nhung |
|---|
| 773 | |tTạp chí Dược học |d2018|gtr. 14-20|i07 |
|---|
| 890 | |c1|a0|b0|d5 |
|---|
| |
Không tìm thấy biểu ghi nào
|
|
|
|