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  • Ký hiệu PL/XG: 615
    Nhan đề: Nghiên cứu định lượng Lornoxicam trong huyết tương bằng phương pháp sắc ký lỏng khối phổ /
DDC 615
Tác giả CN Đồng, Thị Hoàng Yến
Nhan đề Nghiên cứu định lượng Lornoxicam trong huyết tương bằng phương pháp sắc ký lỏng khối phổ / Đồng Thị Hoàng Yến, Nguyễn Thị Dung, Tạ Mạnh Hùng
Tóm tắt An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed for determination of lornoxicam in plasma. The Thermo TSQ Quantum Ultra UPLC-MS/MS operated in the multi reaction-monitoring mode using the electrospray ionization technique. Lornoxicam and the internal standard (Meloxicam) were extracted from plasma by liquid - liquid extraction with diethylether - chloroform. The reconstituted samples were chromatographed on a C18 column (50 x 2.1 mm, i.d., 1.9 µm) with isocratic elution at a flow rate of 0.3 ml/min with 0.1 % formic acid – acetonitrile at a suitable ratio. The standard curves revealed fine linearity at the range of 0.015 to 1.5 µg/ml for lornoxicam with mean correlation coefficient of ≥ 0.99. The intra-day and inter-day precision and accuracy were within 90 % - 110.0 %. The method was well time-saving (the total run time was 2.2 min only), and showed helful for BA-BE studies of lornoxicam preparations.
Thuật ngữ chủ đề Nghiên cứu kỹ thuật -- Việt Nam
Từ khóa tự do Lornoxicam
Từ khóa tự do Sắc ký lỏng khối phổ
Tác giả(bs) CN Nguyễn, Thị Dung
Nguồn trích Tạp chí Dược học 2018tr. 73-77 Số: 11
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0091 0
039|y20191206084851|zthienvan
082 |a615
100 |aĐồng, Thị Hoàng Yến
245 |aNghiên cứu định lượng Lornoxicam trong huyết tương bằng phương pháp sắc ký lỏng khối phổ / |cĐồng Thị Hoàng Yến, Nguyễn Thị Dung, Tạ Mạnh Hùng
520 |aAn ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed for determination of lornoxicam in plasma. The Thermo TSQ Quantum Ultra UPLC-MS/MS operated in the multi reaction-monitoring mode using the electrospray ionization technique. Lornoxicam and the internal standard (Meloxicam) were extracted from plasma by liquid - liquid extraction with diethylether - chloroform. The reconstituted samples were chromatographed on a C18 column (50 x 2.1 mm, i.d., 1.9 µm) with isocratic elution at a flow rate of 0.3 ml/min with 0.1 % formic acid – acetonitrile at a suitable ratio. The standard curves revealed fine linearity at the range of 0.015 to 1.5 µg/ml for lornoxicam with mean correlation coefficient of ≥ 0.99. The intra-day and inter-day precision and accuracy were within 90 % - 110.0 %. The method was well time-saving (the total run time was 2.2 min only), and showed helful for BA-BE studies of lornoxicam preparations.
650 |aNghiên cứu kỹ thuật |z Việt Nam
653 |aLornoxicam
653 |aSắc ký lỏng khối phổ
700 |aNguyễn, Thị Dung
773 |tTạp chí Dược học |d2018|gtr. 73-77|i11
890|c1|a0|b0|d5
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