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  • Ký hiệu PL/XG: 615
    Nhan đề: Định lượng Sofosbuvir trong chế phẩm bằng phương pháp quang phổ UV-VIS, HPLC và CE /

DDC 615
Tác giả CN Phạm, Thị Thanh Thảo
Nhan đề Định lượng Sofosbuvir trong chế phẩm bằng phương pháp quang phổ UV-VIS, HPLC và CE / Phạm Thị Thanh Thảo, Nguyễn Đức Tuấn
Tóm tắt Three methods were developed for quantitative determination of sofosbuvir (recently used for better treatment of hepatitis C virus infection, but without relevant official monograph in the current Vietnamese Pharmacopeia and other reference ones, as well): The first, by UV-Vis spectrophotometry; the second, by HPLC; the third, by CE. These three proposed methods were valiadated, each proving wide range of linearity, high selectivity, good accuracy and precision. On practical application, sofosbuvir in some pharmaceuticals on the local market were quantitatively analyzed by these proposed methods. Accordingly, the contents of sofosbuvir ranged from 95 % to 105 % (calculated on the labeled contents) and without statistically significant differences between the results of any pair of these three methods (p < 0.05).
Thuật ngữ chủ đề Nghiên cứu kỹ thuật --Việt Nam
Từ khóa tự do Phương pháp quang phổ
Từ khóa tự do Sofosbuvir
Tác giả(bs) CN Nguyễn, Đức Tuấn
Nguồn trích Tạp chí Dược học 2018tr. 51-56 Số: 11
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00118654
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004D3712192-5AAA-4837-AED1-A1497C4D606E
005201912050948
008081223s vm| vie
0091 0
039|y20191205094837|zthienvan
082 |a615
100 |aPhạm, Thị Thanh Thảo
245 |aĐịnh lượng Sofosbuvir trong chế phẩm bằng phương pháp quang phổ UV-VIS, HPLC và CE / |cPhạm Thị Thanh Thảo, Nguyễn Đức Tuấn
520 |aThree methods were developed for quantitative determination of sofosbuvir (recently used for better treatment of hepatitis C virus infection, but without relevant official monograph in the current Vietnamese Pharmacopeia and other reference ones, as well): The first, by UV-Vis spectrophotometry; the second, by HPLC; the third, by CE. These three proposed methods were valiadated, each proving wide range of linearity, high selectivity, good accuracy and precision. On practical application, sofosbuvir in some pharmaceuticals on the local market were quantitatively analyzed by these proposed methods. Accordingly, the contents of sofosbuvir ranged from 95 % to 105 % (calculated on the labeled contents) and without statistically significant differences between the results of any pair of these three methods (p < 0.05).
650 |aNghiên cứu kỹ thuật |zViệt Nam
653 |aPhương pháp quang phổ
653 |aSofosbuvir
700 |aNguyễn, Đức Tuấn
773 |tTạp chí Dược học |d2018|gtr. 51-56|i11
890|c1|a0|b0|d5
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