|
DDC
| 615 | |
Tác giả CN
| Bùi, Quang Đông | |
Nhan đề
| Xây dựng phương pháp định lượng Silybin và Isosilybin trong huyết tương Thỏ ứng dụng để đánh giá sinh khả dụng chế phẩm chứa Silymarin / Bùi Quang Đông, Nguyễn Thị Ngọc Thơ, Phạm Đức Tân, Hoàng Thị Trang, Nguyễn Thạch Tùng, Trần Cao Sơn | |
Tóm tắt
| A liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure was established for simultaneous determination of silybin and isosilybin in rabbit plasma, with quercetin as internal standard: Colum – Eclipse plus C10, Mobie phase – acetonitril : formic acid 0.1 %, Mode - gradient; flow rate – 0.5 mL/min, Injection volume – 10 µL. For injection sample, the analyzed plasma was extracted with ethyl acetate by liquid-liquid extraction. The linear range was defined to be 10 to 200 ng.mL-1. The method was validated for selective, linearity, LOD and LOQ… As for practical application, two drug formulations containing silybin and isosilybin were analyzed. The method proved helpul for evaluation of oral bioavailability of silybin and isosilybin preparations. | |
Từ khóa tự do
| Silymarin | |
Từ khóa tự do
| Huyết tương Thỏ | |
Từ khóa tự do
| Silybin và Isosilybin | |
Tác giả(bs) CN
| Nguyễn, Thị Ngọc Thơ | |
Nguồn trích
| Tạp chí Dược học 2018tr. 48-54
Số: 12 |
| |
000
| 00000nab#a2200000ui#4500 |
|---|
| 001 | 18645 |
|---|
| 002 | 9 |
|---|
| 004 | 78D20324-9E8C-4AA6-A33C-3FC719CC54D5 |
|---|
| 005 | 201912050829 |
|---|
| 008 | 081223s vm| vie |
|---|
| 009 | 1 0 |
|---|
| 039 | |y20191205082903|zthienvan |
|---|
| 082 | |a615 |
|---|
| 100 | |aBùi, Quang Đông |
|---|
| 245 | |aXây dựng phương pháp định lượng Silybin và Isosilybin trong huyết tương Thỏ ứng dụng để đánh giá sinh khả dụng chế phẩm chứa Silymarin / |cBùi Quang Đông, Nguyễn Thị Ngọc Thơ, Phạm Đức Tân, Hoàng Thị Trang, Nguyễn Thạch Tùng, Trần Cao Sơn |
|---|
| 520 | |aA liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure was established for simultaneous determination of silybin and isosilybin in rabbit plasma, with quercetin as internal standard: Colum – Eclipse plus C10, Mobie phase – acetonitril : formic acid 0.1 %, Mode - gradient; flow rate – 0.5 mL/min, Injection volume – 10 µL. For injection sample, the analyzed plasma was extracted with ethyl acetate by liquid-liquid extraction. The linear range was defined to be 10 to 200 ng.mL-1. The method was validated for selective, linearity, LOD and LOQ… As for practical application, two drug formulations containing silybin and isosilybin were analyzed. The method proved helpul for evaluation of oral bioavailability of silybin and isosilybin preparations. |
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| 653 | |aSilymarin |
|---|
| 653 | |aHuyết tương Thỏ |
|---|
| 653 | |aSilybin và Isosilybin |
|---|
| 700 | |aNguyễn, Thị Ngọc Thơ |
|---|
| 773 | |tTạp chí Dược học |d2018|gtr. 48-54|i12 |
|---|
| 890 | |c1|a0|b0|d11 |
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