|
DDC
| 615 | |
Tác giả CN
| Nguyễn, Trần Vân Anh | |
Nhan đề
| Tổng hợp và xác định độ tinh khiết tạp chất liên quan D (ethyl 5-amino-1H-pyrazol-4-carboxylat) của Alopurinol / Nguyễn Trần Vân Anh, Lữ Thiện Phúc, Phạm Lê Ngọc Yến, Nguyễn Đức Tuấn | |
Tóm tắt
| Allopurinol impurity D (ethyl 5-amino-1H-pyrazole-4-carboxylate) was synthesized from ethyl (ethoxymethylene) cyanoacetate and hydrazine in the yield of 61.3 % (0.28 gram). By using HPLC – PDA, its chromatographic purity was determined over 99.0 %. As such, the obtained allopurinol impurity D was fairly satisfactory for establishment of the reference substance. Moreover, an HPLC method for purity determination of impurity D was developed as: column - XtimateR C18 (5 µm; 250 4.6 mm); Detector – UV (247 nm; Mobile phase - methanol and water (40:60, v/v); Flow rate - 1.0 mL/min. Validation in observance to ICH guidelines, the method showed to hand wide linearity range (25.16 – 503.10 µg/ml), high precision (RSD £ 0.03 %). The method showed good selectivity, wide linearity range and high precision. | |
Thuật ngữ chủ đề
| Nghiên cứu kỹ thuật --Việt Nam | |
Từ khóa tự do
| Alopurinol | |
Từ khóa tự do
| Độ tinh khiết | |
Tác giả(bs) CN
| Lữ, Thiện Phúc | |
Nguồn trích
| Tạp chí Dược học 2018tr. 32-36
Số: 12 |
| |
000
| 00000nab#a2200000ui#4500 |
|---|
| 001 | 18639 |
|---|
| 002 | 9 |
|---|
| 004 | 82DD1237-4381-4A0A-BB5F-763D8A0C3E57 |
|---|
| 005 | 201912041626 |
|---|
| 008 | 081223s vm| vie |
|---|
| 009 | 1 0 |
|---|
| 039 | |y20191204162639|zthienvan |
|---|
| 082 | |a615 |
|---|
| 100 | |aNguyễn, Trần Vân Anh |
|---|
| 245 | |aTổng hợp và xác định độ tinh khiết tạp chất liên quan D (ethyl 5-amino-1H-pyrazol-4-carboxylat) của Alopurinol / |cNguyễn Trần Vân Anh, Lữ Thiện Phúc, Phạm Lê Ngọc Yến, Nguyễn Đức Tuấn |
|---|
| 520 | |aAllopurinol impurity D (ethyl 5-amino-1H-pyrazole-4-carboxylate) was synthesized from ethyl (ethoxymethylene) cyanoacetate and hydrazine in the yield of 61.3 % (0.28 gram). By using HPLC – PDA, its chromatographic purity was determined over 99.0 %. As such, the obtained allopurinol impurity D was fairly satisfactory for establishment of the reference substance. Moreover, an HPLC method for purity determination of impurity D was developed as: column - XtimateR C18 (5 µm; 250 4.6 mm); Detector – UV (247 nm; Mobile phase - methanol and water (40:60, v/v); Flow rate - 1.0 mL/min. Validation in observance to ICH guidelines, the method showed to hand wide linearity range (25.16 – 503.10 µg/ml), high precision (RSD £ 0.03 %). The method showed good selectivity, wide linearity range and high precision. |
|---|
| 650 | |aNghiên cứu kỹ thuật |zViệt Nam |
|---|
| 653 | |aAlopurinol |
|---|
| 653 | |aĐộ tinh khiết |
|---|
| 700 | |aLữ, Thiện Phúc |
|---|
| 773 | |tTạp chí Dược học |d2018|gtr. 32-36|i12 |
|---|
| 890 | |c1|a0|b0|d10 |
|---|
| |
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