|
DDC
| 615 | |
Tác giả CN
| Lê, Nguyễn Thành | |
Nhan đề
| Tổng hợp một số dẫn chất 6-(n-butylamino)-2-Arylquinazolin-4(3H)-on hướng kháng ung thư / Lê Nguyễn Thành, Trần Minh Huệ, Ngô Xuân Hoàng, Hoàng Thu Trang, Đinh Ngọc Thức, Văn Thị Mỹ Huệ | |
Tóm tắt
| A series of 2-arylquinazolin-4(3H)-on was designed in expectaion of anticancer effects. Substitutions at C6 and C2’ position of the structures were introduced. Targeted compound 6a-d were obtained by a 3-steps pathway from 2-amino-5-butylaminobenzamid and corresponding aldehydes. Cytotoxicity of the synthesized compounds were tested against two cancer cell lines (human epidermic carcinoma-KB and hepatocellular carcinoma-HepG2). As expected, all the tested compounds exhibited stronger cytotoxicity than ellipticine. Notably, compound 6c and 6d exposed the desirable activity 18 - 27 times as strong as ellipticine with IC50 ranging at 0,09-0,12 mM. These findings clarified why the 2-arylquinazolin-4(3H)-on derivatives with 2’-substitution have been considered as very potential anticancer agents. | |
Thuật ngữ chủ đề
| Nghiên cứu kỹ thuật --Việt Nam | |
Từ khóa tự do
| Ung thư | |
Từ khóa tự do
| Arylquinazolin | |
Tác giả(bs) CN
| Trần, Minh Huệ | |
Nguồn trích
| Tạp chí Dược học 2018tr. 75-80
Số: 12 |
| |
000
| 00000nab#a2200000ui#4500 |
|---|
| 001 | 18636 |
|---|
| 002 | 9 |
|---|
| 004 | C5F51250-B1BC-4480-B1AA-9C52CB1A4C5B |
|---|
| 005 | 201912041619 |
|---|
| 008 | 081223s vm| vie |
|---|
| 009 | 1 0 |
|---|
| 039 | |y20191204161939|zthienvan |
|---|
| 082 | |a615 |
|---|
| 100 | |aLê, Nguyễn Thành |
|---|
| 245 | |aTổng hợp một số dẫn chất 6-(n-butylamino)-2-Arylquinazolin-4(3H)-on hướng kháng ung thư / |cLê Nguyễn Thành, Trần Minh Huệ, Ngô Xuân Hoàng, Hoàng Thu Trang, Đinh Ngọc Thức, Văn Thị Mỹ Huệ |
|---|
| 520 | |aA series of 2-arylquinazolin-4(3H)-on was designed in expectaion of anticancer effects. Substitutions at C6 and C2’ position of the structures were introduced. Targeted compound 6a-d were obtained by a 3-steps pathway from 2-amino-5-butylaminobenzamid and corresponding aldehydes. Cytotoxicity of the synthesized compounds were tested against two cancer cell lines (human epidermic carcinoma-KB and hepatocellular carcinoma-HepG2). As expected, all the tested compounds exhibited stronger cytotoxicity than ellipticine. Notably, compound 6c and 6d exposed the desirable activity 18 - 27 times as strong as ellipticine with IC50 ranging at 0,09-0,12 mM. These findings clarified why the 2-arylquinazolin-4(3H)-on derivatives with 2’-substitution have been considered as very potential anticancer agents. |
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| 650 | |aNghiên cứu kỹ thuật |zViệt Nam |
|---|
| 653 | |aUng thư |
|---|
| 653 | |aArylquinazolin |
|---|
| 700 | |aTrần, Minh Huệ |
|---|
| 773 | |tTạp chí Dược học |d2018|gtr. 75-80|i12 |
|---|
| 890 | |c1|a0|b0|d11 |
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