|
DDC
| 615 | |
Tác giả CN
| Nguyễn, Ngọc Chiến | |
Nhan đề
| Tối ưu hóa công thức bào chế tiểu phân Nano Dihydroartemisinin với chất mang Eudragit EPO / Nguyễn Ngọc Chiến, Lê Thị Phương, Trần Trịnh Công | |
Tóm tắt
| Dihydroartemisinin-loaded Eudragit EPO-based nanoparticles were made by oil/water emulsion evaporation. Influence of several formulation factors on physicochemical characteristics of nanoparticles was evaluated to optimize the formulation. Experiments were designed by Modde 8.0 and analyzed by FormRule 2.0 and InForm 3.1 to determine the impacts of three independent variables (ratio of dihydroartemisinin to Eudragit EPO, concentrations of Cremophor A25 and volume of aqueous phase) on some response variables (particle size, polydispersity index, zeta potential, loading capacity and encapsulation efficiency). The optimized formulation was obtained with size of 170 nm, PDI below 0.3, zeta potential of 23.7 mV, encapsulation efficiency of 42.3 % and loading capacity of 11.21 %. | |
Thuật ngữ chủ đề
| Nghiên cứu kỹ thuật --Việt Nam | |
Từ khóa tự do
| Tiểu phân | |
Từ khóa tự do
| Dihydroartemisinin | |
Từ khóa tự do
| Eudragit EPO | |
Tác giả(bs) CN
| Lê, Thị Phương | |
Nguồn trích
| Tạp chí Dược học 2018tr. 3-6
Số: 12 |
| |
000
| 00000nab#a2200000ui#4500 |
|---|
| 001 | 18635 |
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| 002 | 9 |
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| 004 | 175FB0BA-1D88-4B88-9A76-426940F81849 |
|---|
| 005 | 201912041613 |
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| 008 | 081223s vm| vie |
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| 009 | 1 0 |
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| 039 | |y20191204161326|zthienvan |
|---|
| 082 | |a615 |
|---|
| 100 | |aNguyễn, Ngọc Chiến |
|---|
| 245 | |aTối ưu hóa công thức bào chế tiểu phân Nano Dihydroartemisinin với chất mang Eudragit EPO / |cNguyễn Ngọc Chiến, Lê Thị Phương, Trần Trịnh Công |
|---|
| 520 | |aDihydroartemisinin-loaded Eudragit EPO-based nanoparticles were made by oil/water emulsion evaporation. Influence of several formulation factors on physicochemical characteristics of nanoparticles was evaluated to optimize the formulation. Experiments were designed by Modde 8.0 and analyzed by FormRule 2.0 and InForm 3.1 to determine the impacts of three independent variables (ratio of dihydroartemisinin to Eudragit EPO, concentrations of Cremophor A25 and volume of aqueous phase) on some response variables (particle size, polydispersity index, zeta potential, loading capacity and encapsulation efficiency). The optimized formulation was obtained with size of 170 nm, PDI below 0.3, zeta potential of 23.7 mV, encapsulation efficiency of 42.3 % and loading capacity of 11.21 %. |
|---|
| 650 | |aNghiên cứu kỹ thuật |zViệt Nam |
|---|
| 653 | |aTiểu phân |
|---|
| 653 | |aDihydroartemisinin |
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| 653 | |aEudragit EPO |
|---|
| 700 | |aLê, Thị Phương |
|---|
| 773 | |tTạp chí Dược học |d2018|gtr. 3-6|i12 |
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| 890 | |c1|a0|b0|d11 |
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