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  • Ký hiệu PL/XG: 615
    Nhan đề: Tổng hợp và thử hoạt tính kháng Nấm, kháng khuẩn của các dẫn xuất Acyl Benzimidazol-2-Thion /
DDC 615
Tác giả CN Ngô, Duy Túy Hà
Nhan đề Tổng hợp và thử hoạt tính kháng Nấm, kháng khuẩn của các dẫn xuất Acyl Benzimidazol-2-Thion / Ngô Duy Túy Hà, Lê Thọ Tiển, Trương Phương
Tóm tắt To create new chemical compounds of antibacterial and antifungal acitivity, five new benzimidazole-2-thione (BI2T) derivatives were synthesized. They were all characterized by melting point, TLC, and structurally elucidated by UV, IR, 1H-NMR, 13C-NMR and MS. Bioactively, the BI2T acylization was investigated for antibacterial and antifungal activity on the referenced bacteria (Escherichia coli ATCC 25922; Pseudomonas aeruginosa ATCC 27853; Streptococcus faecalis ATCC 29212; methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300) and fungal strains (Candida albicans ATCC 10231; T. mentagrophytes and T. rubrum). Of these five synthesized derivatives, 3a (1-acetylbenzimidazol-2-thion) and 3b (1-Benzoylbenzimidazol-2-thion) compounds displayed moderate antibiological activity against E.coli, MRSA, Candida albicans and T. rubrum. 3e delivative (1-Thiosalicyloylbenzimidazol-2-thion) displayed moderate antibiological activity against MRSA, Candida albicans and T. rubrum. Whereas, 3d delivative (1,3-Disalicyloylbenzimidazol-2-thion) displayed moderate antibiological activity against MRSA ATCC 43300; 3c delivative (1-Salicyloylbenzimidazol-2-thion) just displayed moderate antibiological activity against T. rubrum. These findings may lay basis for further study on synthesis of new antimicrobial drugs in hope of overcoming drug resistance.
Thuật ngữ chủ đề Nghiên cứu kỹ thuật--Việt Nam
Từ khóa tự do Nấm
Từ khóa tự do Acyl Benzimidazol-2-Thion
Từ khóa tự do Hoạt tín
Tác giả(bs) CN Lê, Thọ Tiển
Tác giả(bs) CN Trương, Phương
Nguồn trích Tạp chí Dược học 2019tr. 66-70 Số: 01
000 00000nab#a2200000ui#4500
00118589
0029
00420F82264-EAE3-4464-86C6-78B7811F6C0C
005201912041039
008081223s vm| vie
0091 0
039|y20191204103943|zthienvan
082 |a615
100 |aNgô, Duy Túy Hà
245 |aTổng hợp và thử hoạt tính kháng Nấm, kháng khuẩn của các dẫn xuất Acyl Benzimidazol-2-Thion / |cNgô Duy Túy Hà, Lê Thọ Tiển, Trương Phương
520 |aTo create new chemical compounds of antibacterial and antifungal acitivity, five new benzimidazole-2-thione (BI2T) derivatives were synthesized. They were all characterized by melting point, TLC, and structurally elucidated by UV, IR, 1H-NMR, 13C-NMR and MS. Bioactively, the BI2T acylization was investigated for antibacterial and antifungal activity on the referenced bacteria (Escherichia coli ATCC 25922; Pseudomonas aeruginosa ATCC 27853; Streptococcus faecalis ATCC 29212; methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300) and fungal strains (Candida albicans ATCC 10231; T. mentagrophytes and T. rubrum). Of these five synthesized derivatives, 3a (1-acetylbenzimidazol-2-thion) and 3b (1-Benzoylbenzimidazol-2-thion) compounds displayed moderate antibiological activity against E.coli, MRSA, Candida albicans and T. rubrum. 3e delivative (1-Thiosalicyloylbenzimidazol-2-thion) displayed moderate antibiological activity against MRSA, Candida albicans and T. rubrum. Whereas, 3d delivative (1,3-Disalicyloylbenzimidazol-2-thion) displayed moderate antibiological activity against MRSA ATCC 43300; 3c delivative (1-Salicyloylbenzimidazol-2-thion) just displayed moderate antibiological activity against T. rubrum. These findings may lay basis for further study on synthesis of new antimicrobial drugs in hope of overcoming drug resistance.
650 |aNghiên cứu kỹ thuật|zViệt Nam
653 |aNấm
653 |aAcyl Benzimidazol-2-Thion
653 |aHoạt tín
700 |aLê, Thọ Tiển
700 |aTrương, Phương
773 |tTạp chí Dược học |d2019|gtr. 66-70|i01
890|c1|a0|b0|d12
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