An investigation of the change in facial pain threshold after auricular acupuncture in healthy volunteers: a pilot study / Minh Man Pham Bui, Ngoc Chau Le, Dieu Thuong Thi Tri
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Tài liệu số:1Introduction: Auricular Acupuncture (AA) is both a diagnostic method and a treatment used to relieve pain and alleviate addictions. The effects and biological mechanisms of AA on the human body have been increasingly observed in clinical and experimental studies based on the gate control theory and the endogenous opioids theory. The purpose of this study was to investigate changes in facial pain thresholds among healthy volunteers after applying AA to acupoints on both auricles. Methods: This was a pilot study with a crossover randomized controlled trial design. 66 healthy volunteers with normal hemodynamic indexes were randomly assigned to one of two groups to receive AA treatment at the Shenmen point, Sympathetic point, Adrenal gland point, Jaw point, and Tooth point of either the left or right auricle (phase 1). 7 days later, participants received sham acupuncture at the same points (phase 2). Results: In phase 1, the results showed that AA at these points in either auricle increased the pain threshold of the facial skin statistically significantly (p<0.05). No statistically significant difference was detected in the sham acupuncture phase. Conclusions: This suggests that AA can be used as a non-pharmacological adjunct to facial pain relief.
Efficacy of auricular acupuncture combined with electro- acupuncture and physiotherapy exercise in motor rehabilitation after ischemic stroke / Duong Thi Huong Nguyen, Dieu Th
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Tài liệu số:1Introduction: Auricular acupuncture (AA) is a method of Traditional Medicine that has been used for a long time to treat many diseases, including stroke. This study aimed to examine the effect of auricular acupuncture combined with electro-acupuncture and physiotherapy exercise in the motor rehabilitation of patients with ischemic stroke. Methods: 128 patients after ischemic stroke participated in this RCT, then were randomly assigned to either the AA-study group (auricular acupuncture combined with electro-acupuncture and conventional therapy) or the CT - control group (sham auricular acupuncture combined with electro- acupuncture and conventional therapy). They were treated and monitored for six consecutive weeks. Clinical outcomes were measured using the Barthel Index (BI), Fugl Meyer Assessment (FMA), and Motricity Index (MI) scales at two-time points, including before and six weeks after initiation of the intervention. Results: After six weeks, FMA, BI, and MI scores were significantly higher than before treatment (p < 0.05) in both groups. Specifically, the study group had a statistically significant improvement compared to the control group (p < 0.05). Conclusions: This study shows that auricular acupuncture in combination with electro-acupuncture and physiotherapy exercise was more effective than electro-acupuncture and physiotherapy exercise in improving motor function in patients after ischemic stroke.
Evaluation of postoperative analgesic effect of auricular acupuncture therapy after surgical extraction of mandibular third molar / Minh Man Pham Bui, Dieu Thuong Thi Trinh
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Tài liệu số:1Introduction: Removing the third molar is a common dental surgery that often results in swelling and discomfort, impacting the patient's wellbeing. Previous studies have shown that auricular acupuncture (AA) can effectively alleviate pain after surgery. This study aimed to assess the pain-relieving benefits of AA for patients undergoing third molar surgery. Methods: A clinical trial using a split-mouth design and double-blind methodology was conducted at the Dental Clinic of the University of Medicine and Pharmacy at Ho Chi Minh city between March 2022 and March 2023. Participants had both sides of their third molars extracted, with one side receiving AA in combination with postoperative pain relief medication, and the other side receiving sham AA along with postoperative pain relief medication. Pain levels at 2, 24, 48, and 72 hours after surgery, and the amount of pain medication used was recorded. Additionally, any side effects resulting from the AA treatment were also evaluated. Results: The pain levels measured by the Visual Analog Scale (VAS) decreased over time for both intervention periods after surgery, with statistically significant lower VAS scores observed in the AA time compared to the sham AA time. The amount of 500mg/tablet paracetamol used after the intervention also decreased over time for both periods. At all-time points, the amount of paracetamol used in the AA group was lower than the sham AA group. No adverse effects were reported in either group. Conclusions: AA was effective for relieving pain after madibular third molar surgery and reducing amount of paracetamol tablets.
Correlation of the Fugl Meyer assessment, Motricity Index and Barthel Index scales in the assessment of rehabilitation in post-stroke patients / Duong Thi Huong Nguyen, Dieu T
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Tài liệu số:1Introduction: Measuring scales are an indispensable tool in rehabilitation interventions, especially when you want to intervene with Traditional medicine methods on post-stroke patients. Appropriate scales are a prerequisite to assessing treatment response, the degree of recovery, and the value of the intervention method. The Barthel Index (BI) is a common scale used to measure activity function (activities of daily living - ADL), while the Fugl Meyer Assessment (FMA) and Motricity Index (MI) are commonly used scales to measure motor function. Methods: A descriptive cross-sectional study was conducted on 128 post-stroke patients with hemiplegia from March 2021 to November 2022. Spearman's test assessed the correlation of 3 scales: BI, FMA, and MI. Results: FMA and MI significantly correlate with BI, with correlation coefficients of r = 0.659 and r = 0.748, respectively. The subdomains of FMA, including FMA-UE (upper extremity), FMA-LE (lower extremity), and MI, including MI-UE (upper extremity), MI-LE (lower extremity), TCT (Trunk Control Test), are also highly correlated with BI. Conclusions: Research results show that scales such as FMA and MI strongly correlate with BI and can be a valuable tool to support the comprehensive assessment of motor and activity function in post-stroke patients.
Clinical Profiles of Major Depressive Disorder Based on Age Groups : A Cross-Sectional Study, Vietnam / Phi Nguyen Yen Ho, Tho Quoc Truong, Tram Nhu Thanh Nguyen, Tram Ly Bich
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Tài liệu số:1Introduction: Depression is a common mental disorder; however, no study has investigated adolescent and late-life depression in Vietnam, and little has been done to compare the clinical characteristics among age groups of patients with this condition in the literature. Therefore, the study aims to examine the differences in symptom presentation among adolescents, adults, and the elderly with major depressive disorder (MDD). Methods: A total of 238 patients diagnosed with MDD according to the DSM-5, including 43 aged 10 to 17 years old, 74 aged 18 to 59 years old, and 121 aged 60 and older, were recruited in a cross-sectional study from March to August 2022 at three psychiatric clinics in Ho Chi Minh City. The eligible participant completed an epidemiological questionnaire. Results: All participants exhibited depressed mood, and 58.8% admitted to having suicidal ideation, with an alarming rate among adolescents (72.1%). Adolescents were less likely to experience the symptoms of interest decrease, appetite problems, insomnia, fatigue, and anxious distress than these other groups (p < 0.05). The pattern of symptom profiles in depressed adults largely remained the same in the older patients, except for psychomotor retardation and concentration problems, in which the latter were less likely to exhibit these symptoms compared to the first one (p<0.001). Conclusion: Adolescents appear to experience fewer depressive symptoms than adults and the elderly, while the two later groups show similar clinical presentations. Therefore, the differences in symptoms across age groups necessitate an individual approach and management by clinicians.
Comparison of the long-term efficacy of Tenofovir monotherapy versus Tenofovir and Phyllanthus Amari combination therapy : A randomized controlled trial / Huy Chung Ly, Bay Th
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Tài liệu số:1Introduction: Hepatitis B infection has become a social burden in over the world due to its high prevalence, while the treatments still do not offer the desired effects. Literature showed that combining traditional medicine with modern drugs was able to inhibit the proliferation of the hepatitis B virus, thus making it an effective treatment. To compare the efficacy of Tenofovir monotherapy versus Tenofovir and Phyllanthus Amari combination therapy in chronic hepatitis B patients. Materials and methods: Randomized controlled clinical trial on 200 chronic hepatitis B patients with HBeAg (+); divided into 2 groups: The combination therapy group used Phyllanthus Amari product and Tenofovir for treatment and the monotherapy group with Tenofovir. Results: The serological, biological, and virological responses in the combination therapy group were earlier than those in the monotherapy group. Statistically significant differences in serological responses between the combination therapy versus monotherapy group were achieved from the 3rd (59% versus 33%, p=0.021) to the 18 th month (99% versus 91%, p=0.029). Statistically significant differences in biochemical responses between the combination therapy versus monotherapy group were achieved from the 9th (12% versus 1%, p=0.003) to the 18th month (35% versus 21%, p=0.040). Statistically significant differences in virological response between the combination therapy versus monotherapy group were achieved from the 6th (23% versus 10%, p=0.021) to the 18th month (97% versus 88%, p=0.029). Conclusion: The combination of Tenofovir and the Phyllanthus Amari product is more effective than using only Tenofovir for treatment in chronic hepatitis B patients with HBeAg-positive.
The therapeutic potential of carpal tunnel syndrome by laser acupuncture : A before-after interventional study / Thy Xuan Kieu, Thuong Thi Dieu Trinh
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Tài liệu số:1Background and Aim: Carpal Tunnel Syndrome (CTS) is a common pathology that affects the quality of human life. It is essential to promote clinical intervention studies. Our initial step in this study focused on the cure for CTS and the safety of Laser Acupuncture (LA), which is a type of acupuncture uses low-level laser instead of metal acupuncture needles. Method: This is a before-after interventional study based on a group of 38 CTS patients, ranging from mild to moderate. Intervention using LA 5 times per week for 4 weeks, using low-level laser with a continuous wavelength of 655 nm, wattage of 5 mW/point, dose of 6 J/point, and direction perpendicular to the skin surface, in 10 pressure points on the affected hand, including PC4, PC6, PC7, PC8, LI4, LI10, LI1, HT3, HT7, LU10. The change in the Symptom Severity Scale (SSS), Functional Status Scale (FSS) through the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) and adverse events were monitored to assess the effectiveness and safety of LA. Results: At the second and fourth weeks, respectively, the SSS score decreased from 28 (27-33) to 14 (14-21) and 12 (11-13); this difference was statistically significant (p<0001). Similarly, the FSS score decreased from 13 (13-15) to 8 (8-10), 8 (8-8), and the difference was statistically significant (p<0001). Following the intervention, 37% (CI 95%, 23-53%) of patients experienced complete symptom recovery and 100% experienced complete functional recovery. No side effects were noted during the treatment. Conclusion: LA was initially shown to be safe and effective in the treatment of CTS by improving symptoms and rehabilitation.
Assessment of stability of HbA1c levels in human whole blood samples using immunoassays / Thuan Thi Minh Nguyen, Dung Thi Van Nguyen
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Tài liệu số:1Hemoglobin A1c (HbA1c) levels in whole blood samples are commonly used to diagnose diabetes and monitor the effectiveness of glycemic control. However, there have not been many studies evaluating changes in HbA1c concentration under different storage conditions and analytical methods. The purpose of this study was to evaluate the stability of %HbA1c stored at different temperature conditions using immunoassays in order to improve the quality of HbA1c test. Whole blood samples collected from 10 healthy volunteers were anticoagulated with K2 EDTA and stored at the following temperatures: 20-25 oC, 2-8 oC, and -20 oC. %HbA1c in human whole blood samples at each time point was determined simultaneously on Standard F Analyzer (%HbA1c-S) with reagent kit based on a reflectometry and immunoassay technology, and Erba XL640 system (%HbA1c-E) used immunoturbidimetric method, respectively. %HbA1c was assessed as stable when the difference in HbA1c level at the later time point was not statistically significant (p >0.05) compared with baseline (T0). Results showed that a positive correlation between %HbA1c-S and %HbA1c-E at T0 (r=0.9996) was observed at room temperature. %HbA1c-S was stabilized for 24 hours at 20-25 °C, for 2 days at 2-8°C and for more than 1 month at -20 °C. %HbA1c-E was stable for 12 hours at 20-25°C; less than 1 day at 2-8°C, and less than 1 month at -20°C. In conclusion, human whole blood samples for HbA1c determination can be stored for up to 1 month at -20°C.
Experiences and impacts of stuttering on Vietnamese adults who stutter : A qualitative study / Nhi Tran Thi Y Nguyen, Rachael Unicomb, Laura Hoffman, Nguyen Do Nguyen, Sally H
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Tài liệu số:1Introduction: Findings of experiences and impacts of stuttering on adult people who stutter (PWS) from previous qualitative studies may not be true for PWS in Vietnam, because of cultural, social, and environmental differences. Until now, there has been no study of stuttering in adult Vietnamese PWS, therefore, the aim of this study was to explore the experiences and impacts of stuttering in adult Vietnamese PWS across their lifespan and on different areas of their lives. Methods: This is a qualitative descriptive study. Participants were recruited via the social networking site of the Vietnamese stuttering community (ECHO Vietnam). Each person was screened for developmental stuttering by an experienced and independent speech language therapist. Semi-structured interview was used for data collection. Thematic analysis was used to analyse the data. Results: Fear of stuttering, being teased by friends, unfavorable family reactions made PWS less confident, self-isolated, thereby having negative impacts on studying, working, and social relations. Beside negative experiences, a few showed empathy and support from teachers, relatives, and friends. PWS had low access to stuttering treatment because of lacking of official information on stuttering treatment. Self-help groups have played an active role in the treatment and emotional support for PWS. Conclusion: This study provided preliminary information about the experiences and impacts of stuttering in Vietnamese adult PWS. Further studies are needed to obtain deeper and more comprehensive information. It is necessary, through mass media, especially the internet, to provide information about treatment facilities, or organizations that PWS can join to get counseling about treatment.
Về hợp đồng thông minh / Trần Linh Huân
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Tài liệu số:1Với những đặc tính ưu việt, hợp đồng thông minh được xem là xu hướng tất yếu trong thời đại công nghệ; tuy nhiên, việc tiếp thu và áp dụng loại hợp đồng này tại Việt Nam hiện nay là một thách thức không nhỏ cả về pháp lý và thực tiễn. Vì vậy, cần có sự nghiên cứu, đánh giá lợi ích của hợp đồng thông minh và tìm hiểu kinh nghiệm quốc tế để ban hành khung pháp lý cho loại hợp đồng này.
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