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Subchronic toxicity of proteoglycan f in rats / Vu Thi Thu Hien, Le Danh Tuyen, [...et al] // Tạp chí Nghiên cứu Y học . - Đại học Y Hà Nội. - p. 8-14. - ISSN: 2354-080X
Ký hiệu phân loại (DDC): 616
Present about proteoglycan not only reduces arthritis pain but also prevents complications, because it prevents joint damage, has anti-inflammatory effects. So, Proteoglycan is a solution to relieve pain and prevent osteoarthritis and osteoporosis effectively. The aim of this study is to investigate the subchronic toxicity of Proteoglycan F (proteoglycan from salmon cartilage) in experimental animals. The subchronic toxicity was carried out in Wistar rats according to the guidelines of the World Health Organization on medicinal herbs of origin. The rats were treated with the doses of 40 mg/kg/day and 120 mg/kg/day for a period of 90 consecutive days. After 90 days of treatment, Proteoglycan F did not cause significant dose-related changes in hematological parameters, renal and hepatic functions as well as histopathology tests. These results suggested that Proteoglycan F has no subchronic toxicity in experimental animals.
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