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Tổng hợp và thử hoạt tính kháng khuẩn, kháng nấm của các dẫn chất imin-thioure / Ngô Duy Túy Hà, Hà Văn Huỳnh Anh, Trương Đỗ Quyên, Trương Phương // Tạp chí Dược học . - 2018. - tr. 38-42. - ISSN:
Ký hiệu phân loại (DDC): 615
Three phenylthiourea derivatives were obtained from anilines and ammonium thiocyanate. Further, five 1-benzylidene-3-phenylthiourea derivatives were synthesized by condensation with aromatic aldehydes. All of the newly synthesized compounds were characterized by melting point, thin layer chromatochraphy, structural elucidation by UV, IR, 1H-NMR, 13C-NMR and MS. Tests on antibacterial activitiy showed that none of these synthesized derivatives effective on the pathogenic bacterial species tested. But, most of them were effective on Candida, especially 1-(4-nitrobenzylidene)-3-phenylthiourea and 1-(3-nitrobenzylidene)-3-phenylthiourea.
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