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Tổng hợp, hoạt tính kháng khuẩn và kháng nấm của dẫn chất N - thế acid anthranilic / Phan Cường Huy,Phạm Cảnh Em, Đỗ Thị Thúy, Trương Ngọc Tuyền // Tạp chí Dược học . - 2018. - tr. 29-32. - ISSN:



Ký hiệu phân loại (DDC): 615
Regarding anthranilic acid as a frequent constituent of many bioactive compounds possessing wide ranges of biological activities, and the nucleus of anthranilic acid is the biochemical precursor of amino acids themselves, their derivatives several alkaloids as well, four N-substituted derivatives of anthranilic acid were synthesized in good yields. The structures of the synthesized derivatives were confirmed by IR, 1H-NMR and MS. In bioactivity, the synthesized derivatives were evaluated for in vitro antifungal and antimicrobial properties on 5 fungal and 4 microbial strains. These derivatives showed no effect on bacteria but average inhibition on T.mentagrophytes and M. gypseum (compound 1 and 4).
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