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Phát hiện tân dược nhóm ức chế Enzym Phosphodiesterase 5 trộn trái phép trong thuốc đông dược và thực phẩm chức năng bằng kỹ thuật vân tay cộng hưởng từ hạt nhân (1H-NMR fingerprint) / Đào Thị Thanh Hiền, Nguyễn Lâm Hồng, Trần Việt Hùng // Tạp chí Dược học . - 2018. - tr. 56-61. - ISSN:



Ký hiệu phân loại (DDC): 615
1H-NMR spectroscopy was used for detecting the presence and identification of phosphodiesterase-5 enzyme inhibitors (PDE-5i) medicines (such as sildenafil, tadalafil, vardenafil and their analogues) as frequent adulterants in dietary supplements (DS) or herbal medicines marketed for improving sexual performance, which were claimed to contain only natural compounds, plant extracts and/or vitamins. A follow-up over time of several DSs revealed that manufacturers made illegal changes in the chemical composition of the formulations, adding forbidden ingredients. It is for the first time in Vietnam, 1H NMR was used as a complementary method for detecting DS adulterated with phosphodiesterase-5 enzyme inhibitors (PDE-5i). On practical application, two DSs were analyzed showing to be adulterated with 2 phosphodiesterase-5 enzyme inhibitors (PDE-5i) (tadalafil, vardenafill) and DS M6 was mixed with 2 sildernafil structurally modified analogues. And furthemore, these proved 1H-NMR spectroscopy to be powerful as a first-line method for the detection of adulterated herbal/natural DS, and n the other hand, called for more effective quality control of natural DS.
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