Dòng Nội dung
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Tổng hợp và thử hoạt tính sinh học của một số dẫn chất N-Hydroxybenzamid mới mang khung 2-Methylquinazolin-4(3H)-on / Nguyễn Thị Thuận, Đoàn Thanh Hiếu, Phan Thị Phương Dung // Tạp chí Dược học . - 2018. - tr. 65-67, 85. - ISSN:



Ký hiệu phân loại (DDC): 615
Four novel N-hydroxybenzamides incorporating 2-methylquinazolin-4(3H)-one were synthesized and evaluated for cytotoxicity against the 3 folloing human cancer cell lines: SW620 (colon), PC-3 (prostate) and NCI-H23 (lung). These compounds were obtained in good yield from corresponding 2-aminobenzoic acids via a four-step synthetic pathway. These synthesized compounds all four showed strong cytotoxicity against the 3 tested cell lines with IC50 values of 0.46-3.88 µM, matchable or even stronger than SAHA (IC50 values of 2.80-3.14 µM, a positive control). Also, by Hela cell nuclear extract assay, the synthesized compounds exhibited strong HDAC inhibition with IC50 values of 0.62-1.190 µM.
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