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Định lượng Sofosbuvir trong chế phẩm bằng phương pháp quang phổ UV-VIS, HPLC và CE / Phạm Thị Thanh Thảo, Nguyễn Đức Tuấn // Tạp chí Dược học . - 2018. - tr. 51-56. - ISSN:
Ký hiệu phân loại (DDC): 615
Three methods were developed for quantitative determination of sofosbuvir (recently used for better treatment of hepatitis C virus infection, but without relevant official monograph in the current Vietnamese Pharmacopeia and other reference ones, as well): The first, by UV-Vis spectrophotometry; the second, by HPLC; the third, by CE. These three proposed methods were valiadated, each proving wide range of linearity, high selectivity, good accuracy and precision. On practical application, sofosbuvir in some pharmaceuticals on the local market were quantitatively analyzed by these proposed methods. Accordingly, the contents of sofosbuvir ranged from 95 % to 105 % (calculated on the labeled contents) and without statistically significant differences between the results of any pair of these three methods (p < 0.05).
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