Dòng Nội dung
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Thẩm định phương pháp phân tích định lượng Famotidin trong huyết tương Thỏ / Phan Thị Huyền Vy, Bùi Minh Thy, Phùng Thị Kim Huệ, Nguyễn Xuân Thành, Triệu Nguyên Trung // Tạp chí Dược học . - 2018. - tr. 32-38. - ISSN:



Ký hiệu phân loại (DDC): 615
As delivery systems of bacterial cellulose are usually used for famotidine, which is a gastrointestinal drug, acting as H2-receptor blocker, to improve its inherent low bioavailability; the created BC-networks ensured the drug prolonged-release therapy, the bioavailability of famotidine loaded in such BC-networks were evaluated by quantitative determination of famotidine in biological fluids, specifically rabbit’s plasma by HPLC. The method was validated for specificity and selectivity, calibration and linearity, limit of detection, precision and accuracy, extraction recovery,…
 Số bản sách: (0) Tài liệu số: (1)
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Xây dựng phương pháp định lượng Silybin và Isosilybin trong huyết tương Thỏ ứng dụng để đánh giá sinh khả dụng chế phẩm chứa Silymarin / Bùi Quang Đông, Nguyễn Thị Ngọc Thơ, Phạm Đức Tân, Hoàng Thị Trang, Nguyễn Thạch Tùng, Trần Cao Sơn // Tạp chí Dược học . - 2018. - tr. 48-54. - ISSN:



Ký hiệu phân loại (DDC): 615
A liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure was established for simultaneous determination of silybin and isosilybin in rabbit plasma, with quercetin as internal standard: Colum – Eclipse plus C10, Mobie phase – acetonitril : formic acid 0.1 %, Mode - gradient; flow rate – 0.5 mL/min, Injection volume – 10 µL. For injection sample, the analyzed plasma was extracted with ethyl acetate by liquid-liquid extraction. The linear range was defined to be 10 to 200 ng.mL-1. The method was validated for selective, linearity, LOD and LOQ… As for practical application, two drug formulations containing silybin and isosilybin were analyzed. The method proved helpul for evaluation of oral bioavailability of silybin and isosilybin preparations.
 Số bản sách: (0) Tài liệu số: (1)