Dòng Nội dung
1
Xác định tổng hàm lượng Silybin A, Silybin B và Isosilybin A trong một số thực phẩm bảo vệ sức khỏe công bố có chứa Silymarin / Lê Đình Chi, Cao Công Khánh // Tạp chí Dược học . - 2018. - tr. 29-32. - ISSN:



Ký hiệu phân loại (DDC): 615
An HPLC method was developed for simultaneous determination of silybin A, silybin B and isosilybin A in health supplement products, as: Column - Symmetry C18; Detector - UV-Vis (288 nm); Mobile phase - a mixture of 20 mM sodium perchlorate pH 3.0 and methanol, in gradient mode; Flow rate - 1.0 ml/min; Injection volume - 50 ml. The method was fully validated and proved suitable for the intended application. To prove the practical appliability, 12 encapsuled health supplement products were analyzed. All the tested samples contained silymarin as declared on the label, but quantitatively, the total content of silybin A, silybin B and isosilybin A as a whole ranged just from 15.8 to 69.1 % of their labeled amount.
 Số bản sách: (0) Tài liệu số: (1)
2
Xây dựng phương pháp định lượng Silybin và Isosilybin trong huyết tương Thỏ ứng dụng để đánh giá sinh khả dụng chế phẩm chứa Silymarin / Bùi Quang Đông, Nguyễn Thị Ngọc Thơ, Phạm Đức Tân, Hoàng Thị Trang, Nguyễn Thạch Tùng, Trần Cao Sơn // Tạp chí Dược học . - 2018. - tr. 48-54. - ISSN:



Ký hiệu phân loại (DDC): 615
A liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure was established for simultaneous determination of silybin and isosilybin in rabbit plasma, with quercetin as internal standard: Colum – Eclipse plus C10, Mobie phase – acetonitril : formic acid 0.1 %, Mode - gradient; flow rate – 0.5 mL/min, Injection volume – 10 µL. For injection sample, the analyzed plasma was extracted with ethyl acetate by liquid-liquid extraction. The linear range was defined to be 10 to 200 ng.mL-1. The method was validated for selective, linearity, LOD and LOQ… As for practical application, two drug formulations containing silybin and isosilybin were analyzed. The method proved helpul for evaluation of oral bioavailability of silybin and isosilybin preparations.
 Số bản sách: (0) Tài liệu số: (1)