Dòng Nội dung
1
Biến cố trên Thận và trên thính giác trong điều trị Lao đa kháng ghi nhận qua hoạt động giám sát tích cực tại Việt Nam / Nguyễn Thị Thủy, Cao Thị Thu Huyền, Nguyễn Bảo Ngọc, Dương Văn Quang, Vũ Đình Hòa, Nguyễn Hoàng Anh, Nguyễn Viết Nhung // Tạp chí Dược học . - 2018. - tr. 11-15. - ISSN:



Ký hiệu phân loại (DDC): 615
Ototoxity and nephrotoxicity as the main causes of adverse events of injectable anti-tuberculosis drugs were investigated by a prospective study based on a Cohort Event Monitoring (CEM) program in 9 sentinel sites in Vietnam from April 2014 to December 2016. The study involved a cohort of 659 of MDR-TB patients. Of these, 7.4% experienced at least one renal adverse event each, and 15.2% were affected by ototoxicity during treatment. Multivariate regression analysis revealed a history of existing renal/hearing problems related to nephrotoxicity/ototoxicity, respectively. Meanwhile, it was the daily dose of the injectable drugs that appeared as a risk factor to both types of the AEs. In Vietnam, nephrotoxicity and ototoxicity were quite common in MDR-TB treatment, therefore, certainly resposonsible for the MDR-TB relared renal failure and irreversible hearing loss. The findings of the related factors to nephrotoxicity and ototoxicity by this study posed weight on patient history investigation, baseline examination and close monitoring of renal function and audiometry in patients treated by MDR-TB regimens, especially those consisting of injectable drugs of the kind.
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2
Các hợp chất Flavonoid và dẫn xuất của Acid Prenylbenzoic từ cây Nhục Tử gần (Sarcosperma affinis Gagnep.) / Nguyễn Thị Hoài // Tạp chí Dược học . - 2018. - tr. 45-47, 72. - ISSN:



Ký hiệu phân loại (DDC): 615
Two flavonoids, (-)-epicatechin (1) and quercetin-3-O-β-D-galactopyranoside (2), and one prenylbenzoic acid derivative, 3-prenyl-4-O-β-D-glucopyranosyloxy-4-hydroxylbenzoic acid (3), were isolated from the aerial parts of Sarcosperma affinis Gagnep.. Their chemical structures were determined on the basis of spectroscopic analyses in reference to the literary. These compounds were obtained from Sarcosperma genus for the first time.
Số bản sách: (0) Tài liệu số: (1)
3
Định danh một số mẫu Sâm mang tên Sâm Ngọc Linh bằng cách giải trình tự đoạn ITS / Phạm Thị Minh Tâm, Nguyễn Hữu Sơn, Nguyễn Thị Ngọc Linh, Huỳnh Thị Thanh Thượng, Nguyễn Thị Ánh Nguyệt, Trần Việt Hùng // Tạp chí Dược học . - 2018. - tr. 35-40. - ISSN:



Ký hiệu phân loại (DDC): 615
Nine samples, all in the same vernacular name of “Ngoc Linh Ginseng” in confusion were investigated by DNA-sequencing the ITS region. Of these, seven were Panax vietnamensis Ha & Grushv., belong to the same group with Panax ginseng Baill and Panaxquinquefolius L.. As for other two samples, one was Panax notoginseng (Burkill) F. H. Chen ex C. Y. Wu & K. M. Feng and the last one was not belong to Araliaceae family.
Số bản sách: (0) Tài liệu số: (1)
4
Định lượng Domperidon trong huyết tương người bằng phương pháp sắc ký lỏng siêu hiệu năng ghép nối với Detector khối phổ (UPLC-MS/MS) / Tạ Mạnh Hùng, Phạm Thanh Huyền, Phan Thị Nghĩa // Tạp chí Dược học . - 2018. - tr. 29-34. - ISSN:



Ký hiệu phân loại (DDC): 615
An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed for determination of domperidone in human plasma with diphenhydramine as internal standard: Column - C18 (150 x 4.6mm, i.d., 5 µm); mobile phase - 0.05% formic acid - methanol - acetonitrile - isopropanol (suitable ratio); flow rate - 0.5 ml/min (isocratic elution). The UPLC-MS/MS was operated in the multi reaction-monitoring mode using the electrospray ionization technique. For injection samples, domperidone and the internal standard (diphenhydramine) were extracted from human plasma by liquid-liquid extraction with a mixture of diethylether and chloroform. Good linearity for standard curves was found at the range of 0.5 to 50 ng/ml for domperidone (mean correlation coefficient R2 ≥ 0.99). The intra-day and inter-day precision and accuracy were within 88.8% - 106.8%. The method was excellently time-saving - the total run time was 4 min only. This method showed applicable to BA-BE studies of domperidone preparations.
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5
Định lượng Sofosbuvir trong chế phẩm bằng phương pháp quang phổ UV-VIS, HPLC và CE / Phạm Thị Thanh Thảo, Nguyễn Đức Tuấn // Tạp chí Dược học . - 2018. - tr. 51-56. - ISSN:



Ký hiệu phân loại (DDC): 615
Three methods were developed for quantitative determination of sofosbuvir (recently used for better treatment of hepatitis C virus infection, but without relevant official monograph in the current Vietnamese Pharmacopeia and other reference ones, as well): The first, by UV-Vis spectrophotometry; the second, by HPLC; the third, by CE. These three proposed methods were valiadated, each proving wide range of linearity, high selectivity, good accuracy and precision. On practical application, sofosbuvir in some pharmaceuticals on the local market were quantitatively analyzed by these proposed methods. Accordingly, the contents of sofosbuvir ranged from 95 % to 105 % (calculated on the labeled contents) and without statistically significant differences between the results of any pair of these three methods (p < 0.05).
Số bản sách: (0) Tài liệu số: (1)