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Tổng hợp một số dẫn chất 6-(n-butylamino)-2-Arylquinazolin-4(3H)-on hướng kháng ung thư / Lê Nguyễn Thành, Trần Minh Huệ, Ngô Xuân Hoàng, Hoàng Thu Trang, Đinh Ngọc Thức, Văn Thị Mỹ Huệ // Tạp chí Dược học . - 2018. - tr. 75-80. - ISSN:



Ký hiệu phân loại (DDC): 615
A series of 2-arylquinazolin-4(3H)-on was designed in expectaion of anticancer effects. Substitutions at C6 and C2’ position of the structures were introduced. Targeted compound 6a-d were obtained by a 3-steps pathway from 2-amino-5-butylaminobenzamid and corresponding aldehydes. Cytotoxicity of the synthesized compounds were tested against two cancer cell lines (human epidermic carcinoma-KB and hepatocellular carcinoma-HepG2). As expected, all the tested compounds exhibited stronger cytotoxicity than ellipticine. Notably, compound 6c and 6d exposed the desirable activity 18 - 27 times as strong as ellipticine with IC50 ranging at 0,09-0,12 mM. These findings clarified why the 2-arylquinazolin-4(3H)-on derivatives with 2’-substitution have been considered as very potential anticancer agents.
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