Dòng Nội dung
1
Nghiên cứu bào chế Hydrogel chứa tiểu phân Niosome Tadalafil / Nguyễn Ngọc Chiến, Phạm Thị Mai Anh // Tạp chí Dược học . - 2019. - tr. 13-16,35. - ISSN:



Ký hiệu phân loại (DDC): 615
Tadalafil loaded niosomes were formed by ethanol injection method. Suspension were prepared with tadalafil as the core, span 60 and cholesterol as coating materials and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as stabilizer. The oil phase containing Span 60, cholesterol and tadalafil was injected into a solution of TPGS 0.2% as the water phase by a high speed mixer at 300 rpm for 2 minutes at 650C. The obtained suspensions were stirred at 150 rpm for 1 hr to evaporate ethanol. The final hydogels were achieved by dispersion of xanthan gum and a permeability enhancer into the tadalafil niosomes. The drug release of the formulated hydrogels reached up to 21.11 ± 0.40% after 6 hours as measured with Franz diffusion cells.
 Số bản sách: (0) Tài liệu số: (1)
2
Tối ưu hóa công thức bào chế tiểu phân Nano Dihydroartemisinin với chất mang Eudragit EPO / Nguyễn Ngọc Chiến, Lê Thị Phương, Trần Trịnh Công // Tạp chí Dược học . - 2018. - tr. 3-6. - ISSN:



Ký hiệu phân loại (DDC): 615
Dihydroartemisinin-loaded Eudragit EPO-based nanoparticles were made by oil/water emulsion evaporation. Influence of several formulation factors on physicochemical characteristics of nanoparticles was evaluated to optimize the formulation. Experiments were designed by Modde 8.0 and analyzed by FormRule 2.0 and InForm 3.1 to determine the impacts of three independent variables (ratio of dihydroartemisinin to Eudragit EPO, concentrations of Cremophor A25 and volume of aqueous phase) on some response variables (particle size, polydispersity index, zeta potential, loading capacity and encapsulation efficiency). The optimized formulation was obtained with size of 170 nm, PDI below 0.3, zeta potential of 23.7 mV, encapsulation efficiency of 42.3 % and loading capacity of 11.21 %.
 Số bản sách: (0) Tài liệu số: (1)