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Acute and sub chronic toxicity assessment of Dong Trung Ga Thao sapa capsules in experimental animals / Do Dieu Linh, Pham Thi Van Anh, [...et al] // Tạp chí Nghiên cứu Y học . - 2020. - p. 57-65. - ISSN: 2354-080X
Ký hiệu phân loại (DDC): 615
Present about “Dong trung ha thao Sapa” capsules prepared from Cordyceps militaris powder are intended to use for male hypogonadism treatment. So far, the safety of this product has not yet been reported. This study is to evaluate the acute and sub chronic oral toxicity of “Dong trung ha thao Sapa” capsules in experimental animals. The acute toxicity evaluation was carried out according to Litchfield Wilcoxon’s method in Swiss mice. Mice were administered orally with increasing doses in the same volume to determine the lowest dose causing 100% death in mice and the highest dose causing no death in mice. The sub-chronic toxicity was evaluated according to WHO and OECD guidelines in Wistar rats with oral doses of 252 mg/kg b.w/day and 756 mg/kg b.w/day in 90 consecutive days. In the course of the acute toxicity test, mice showed no abnormal signs or death. At two doses 252 mg/kg b.w/day and 756 mg/kg b.w/day, the sub chronic toxicity study did not change the rats’ body weight, hematological, biochemical parameters, and microscopic of the livers and kidneys during the study period. In conclusion, “Dong trung ha thao Sapa” capsules do not appear to produce acute toxicity in mice and sub chronic toxicity in rats.
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