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Rowland and Tozer's clinical pharmacokinetics and pharmacodynamics : concepts and applications / Hartmut Derendorf, Stephan Schmidt, Malcolm Rowland
Philadelphia : Wolters Kluwer, 2020
xxiii, 939 pages : color illustrations ; 26 cm.
Ký hiệu phân loại (DDC): 615.7
Updated with the latest clinical advances, Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications
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The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: The EUCAST approach, Clinical Microbiology and Infection / Mouton JW et al.
Basel : European Society of Clinical Microbiology and Infectious Diseases.
p ; cm.
Ký hiệu phân loại (DDC): 615.7
Clinical breakpoints are used in clinical microbiology laboratories to categorize microorganisms as clinically susceptible (S), intermediate (I) or resistant (R) dependent on the quantitative antimicrobial susceptibility as indicated by the MIC value determined in a well-defined standard test system. The laboratory report, with the designations of S, I or R for each antimicrobial agent, provides guidance to clinicians with respect to the potential use of agents in the treatment of patients, and clinical breakpoints should therefore distinguish between patients that are likely or unlikely to respond to antimicrobial treatment. In Europe, clinical breakpoints are set by the European Committee on Antimicrobial Susceptibility Testing (EUCAST), following a defined procedure. This includes evaluation of efficacy in experimental settings and clinical studies to derive pharmacodynamic targets such as the fAUC/MIC ratio or %fT > MIC required for efficacy, the pharmacokinetic properties of the agent, Monte Carlo simulations to estimate exposures of the antimicrobial agent in the target patient population and commonly used dosing regimens
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