Dòng Nội dung
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Clinical Profiles of Major Depressive Disorder Based on Age Groups : A Cross-Sectional Study, Vietnam / Phi Nguyen Yen Ho, Tho Quoc Truong, Tram Nhu Thanh Nguyen, Tram Ly Bich Nguyen, Manh Xuan Bui, Ngoc Anh Tran, Chau Thi Minh Pham, Phu Thi Nguyen, Phan Ngoc Ai, Nghia Trung Tran, Linh Tich Ngo // MedPharmRes . - 2023. - tr. 109-114. - ISSN: 2615-9139



Ký hiệu phân loại (DDC): 616.8527
Introduction: Depression is a common mental disorder; however, no study has investigated adolescent and late-life depression in Vietnam, and little has been done to compare the clinical characteristics among age groups of patients with this condition in the literature. Therefore, the study aims to examine the differences in symptom presentation among adolescents, adults, and the elderly with major depressive disorder (MDD). Methods: A total of 238 patients diagnosed with MDD according to the DSM-5, including 43 aged 10 to 17 years old, 74 aged 18 to 59 years old, and 121 aged 60 and older, were recruited in a cross-sectional study from March to August 2022 at three psychiatric clinics in Ho Chi Minh City. The eligible participant completed an epidemiological questionnaire. Results: All participants exhibited depressed mood, and 58.8% admitted to having suicidal ideation, with an alarming rate among adolescents (72.1%). Adolescents were less likely to experience the symptoms of interest decrease, appetite problems, insomnia, fatigue, and anxious distress than these other groups (p < 0.05). The pattern of symptom profiles in depressed adults largely remained the same in the older patients, except for psychomotor retardation and concentration problems, in which the latter were less likely to exhibit these symptoms compared to the first one (p<0.001). Conclusion: Adolescents appear to experience fewer depressive symptoms than adults and the elderly, while the two later groups show similar clinical presentations. Therefore, the differences in symptoms across age groups necessitate an individual approach and management by clinicians.
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Somatic Symptoms in Major Depressive Disorder : A Cross-sectional Study in a Mental Health Setting, Vietnam / Phi Nguyen Yen Ho, Chau Minh Pham, Manh Xuan Bui, Ngoc Anh Tran, Nghia Trung Tran, Quynh Ho Ngoc Huynh, Linh Tich Ngo, Huy Tien Nguyen // MedPharmRes . - 2023. - tr. 42-48. - ISSN: 2615-9139



Ký hiệu phân loại (DDC): 616.8527
Introduction: Major depressive disorder (MDD) presents a diverse clinical picture, especially with somatic symptoms, which can lead to negative impacts on the course and prognosis of the illness. This study aimed to (1) assess the prevalence of various somatic symptoms in MDD patients and (2) assess their association with demographic factors. Methods: A total of 345 outpatients diagnosed with MDD according to DSM-5 criteria were enrolled in this cross-sectional study over 6 months. Participants completed a questionnaire that included clinical and demographic information as well as the PHQ-9. Results: There were 99.7% of patients who had at least one somatic symptom. The common somatic symptoms were fatigue (89.9%), insomnia (87.8%), palpitations (77.7%), headache (69.6%) and dizziness (61.4%). Total PHQ-9 scores and total number of somatic symptoms were found to have a regression relationship with a regression coefficient of 0.14 (t = 6.001, p < 0.001). In multiple logistic regression analysis, female gender was found to be associated with dizziness (odd ratios [OR] = 2.54, 95% confidence interval [CI] 1.53-4.21, p < 0.01), headaches (OR = 1.94, 95% CI 1.16-3.32, p < 0.05), and bowel problems (OR = 0.59, 95% CI 0.37-0.96, p < 0.05); while headaches (OR = 1.73, 95% CI 1.05-2.85, p < 0.05), and stomach problems (OR = 0.56, 95% CI 0.36-0.88, p < 0.05) were associated with age 40 and below. Conclusions: The study findings provide a resource for clinicians in mental health settings as well as primary care clinics in detecting inexplicable somatic symptoms associated with MDD.
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