Dòng Nội dung
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Nghiên cứu xây dựng phương pháp định tính nhanh một số glucocorticoid ngụy tạo trong thực phẩm chức năng hỗ trợ điều trị viêm, thấp khớp bằng kỹ thuật phối khổ / Hà Ánh Xương, Đỗ Châu Minh Vĩnh Thọ // Tạp chí Dược học . - 2020. - Tr. 74-79. - ISSN:


6 tr.
Ký hiệu phân loại (DDC): 615
A direct infusion MS/MS method was validated for rapid simultaneous determination of (1) betamethasone. (2) dexamethasone, (3) dexamethasone acetate, (4) fluocinolone acetonide, (5) methylprednisolone. (6) prednisoione, (7) tn‘amcinolon acetonide, (8) clobetasol propionate, (9) hydrocortisone acetate, (10) prednisolon acetate, (11) prednison as adulterants in dietary supplements for arthritis treatment. The MS/MS procedure was experimentally optimized as: Capillary voltage - 3.8 kV, desolvation temperature - 400°C, gas flow rate - 900 L/h, cone voltage - 15V, and collision cell energy - 12V and 18% Forinjection sample, the controlled sample was dissolved in a methanolic solution offormic acid 0.1% (70:30) by 10 minutes‘ ultrasonication. Validation proved the method having high specificity and a very good limit ofdetection (1.8-4.6 ppb and 007—1. 14 ppb for M81 full scan and daughters scan mode, respectively. As for practical tests, 45 supplementaryproducts for arthritis treatment were controlled, of these, 17 (37. 7%) were revealed to contain the adulterant corticosteroids in question.
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2
Nghiên cứu xây dựng qui trình phân tích một số Glucocorticoid ngụy tạo trong mỹ phẩm điều trị mụn, làm trắng da bằng phương pháp LC-MS-MS / Nguyễn Quốc Tuấn, Đỗ Châu Minh Vĩnh Thọ // Tạp chí Dược học . - 2018. - tr. 67-72. - ISSN:



Ký hiệu phân loại (DDC): 615
A reversed-phase LC-MS-MS method was developed for simultaneous determination of dexamethasone acetate (DXA), betamethasone (BM), prednisolone (PR), triamcinolone acetonide (TCA) in cosmetics treating acne or for skin whitening. The procdure was optimized as: Column - Phenomenex Gemini C-18 (150 x 4.6 mm, 5μm); Mobile phase - ACN-H2O in gradient mode; Sample injection volume - 5μl; Electrospray ionnization source was operated in positive mode and multi reaction monitoring (MRM) mode using the transition of m/z 435.20 " 397.25; m/z 393.11 " 147.06; m/z 361.22 "147.13; m/z 345.20 "397.25 and m/z 375.18 "161.17 were used to quantify DXA, BM, PR, TCA and methyl prednisolone (IS), respectively. Validated in accordance to AOAC guidelines, the method proved to meet the requirements: Wide linearity range (20-750ppb) and high correlation coefficient (R2> 0.9982), very good accuracy (recovery rate - 90.2– 112.2%) and intra-day precision (RSD < 6.5%), typical LOD, LOQ values (0.1-0.3ppb and 0.33-9.9ppb for each of all four glucocorticoids). On practical application, 20 commercial cosmetic products for acnes and whitening skin Tra Vinh province was controlled to determine these four corticoids. Of these cosmetics, 35% were detected to be adulterated with corticosteroids.
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3
Xây dựng qui trình phân tích một số Glucocorticoid ngụy tạo trong chế phẩm dược liệu bằng phương pháp UHPLC-UV-Vis / Trần Ngọc Luân, Đỗ Châu Minh Vĩnh Thọ, Nguyễn Đức Tuấn // Tạp chí Dược học . - 2018. - tr. 41-44. - ISSN:



Ký hiệu phân loại (DDC): 615
A simple reversed phase UHPLC-UV-Vis method was developed for simultaneous determination of prednisolone, methylprednisolone, betamethasone, and dexamethasone acetate adulterated in herbal medicines used for treatment of rheumatoid arthritis. The method was estalished as: Column - Thermo Acclamide Polar C16 (4.6 x 250 mm; 5µm); Mobile phase - acetonitrile and water in gradient mode; Flow rate - 1 ml/min; Detector – UV (240 nm). Validated in observane to the AOAC guidelines, the proposed method showed to meet well the all the requirements: suitability for UHPLC system, selectivity, linearity range (R2 > 0.995), accuracy (recoveries in the range of 90% - 107%), and precision (RSD < 5.3%), and high sensitivity (LOD: 0.32 ppm, LOQ: 1.3 ppm). For practical tets, these four glucocorticoids were analyized in 30 available herbal products; of these five were found illegally aldulterated with corticoids.
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