|
DDC
| 615 | |
Nhan đề
| Nghiên cứu sàng lọc ảo các chất có khả năng hoạt hóa enzym y—secretase / Trần Thái Sơn, [.... và những người khác] | |
Mô tả vật lý
| 6 tr. | |
Tóm tắt
| Regarding Alzheimer’s disease (AD) is one of the main causes of dementia symptoms in the elderty, in the line of finding new y-secretase modulators (GSMs) for its treatment, the 3D-pharmacophore, ZD-QSAR, machine Ieaming and docking were built with database of 137 y—secretase modulators and crystal stnrcture 6IYC by the softwares LigandScout 4.3, MOE 2015.10 and Leal 2.1.8 for virtual screeing the Drug Bank, Traditional Chinese Medicine Database (TCM), ZINC12 database containing 22. 790.447 compounds. By this virtual screening, 2003 compounds were obtained and docked successfully. The study may promote further screenings on other databases and molecular dynamic studies, in vitro and in vivo tests ofpromising potential substances. | |
Từ khóa tự do
| Bệnh mất trí nhớ | |
Từ khóa tự do
| Virtual screening | |
Từ khóa tự do
| Alzheimer's disease | |
Từ khóa tự do
| Enzym y—secretase | |
Từ khóa tự do
| GSMs | |
Từ khóa tự do
| Hoạt hóa enzym y—secretase | |
Tác giả(bs) CN
| Trần, Thái Sơn | |
Tác giả(bs) CN
| Võ, Lưu Hoàng Tuấn | |
Tác giả(bs) CN
| Lê, Minh Trí | |
Tác giả(bs) CN
| Nguyễn, Hoàng Tiến | |
Nguồn trích
| Tạp chí Dược học 2020Tr. 19-24
Số: 03 |
| |
000
| 00000nab#a2200000ui#4500 |
|---|
| 001 | 20746 |
|---|
| 002 | 9 |
|---|
| 004 | 45829F30-778A-45A6-BDFE-B4EAC4E74734 |
|---|
| 005 | 202004221134 |
|---|
| 008 | 081223s vm| vie |
|---|
| 009 | 1 0 |
|---|
| 039 | |y20200422113410|zngantk |
|---|
| 082 | |a615 |
|---|
| 245 | |aNghiên cứu sàng lọc ảo các chất có khả năng hoạt hóa enzym y—secretase / |cTrần Thái Sơn, [.... và những người khác] |
|---|
| 300 | |a6 tr. |
|---|
| 520 | |aRegarding Alzheimer’s disease (AD) is one of the main causes of dementia symptoms in the elderty, in the line of finding new y-secretase modulators (GSMs) for its treatment, the 3D-pharmacophore, ZD-QSAR, machine Ieaming and docking were built with database of 137 y—secretase modulators and crystal stnrcture 6IYC by the softwares LigandScout 4.3, MOE 2015.10 and Leal 2.1.8 for virtual screeing the Drug Bank, Traditional Chinese Medicine Database (TCM), ZINC12 database containing 22. 790.447 compounds. By this virtual screening, 2003 compounds were obtained and docked successfully. The study may promote further screenings on other databases and molecular dynamic studies, in vitro and in vivo tests ofpromising potential substances. |
|---|
| 653 | |aBệnh mất trí nhớ |
|---|
| 653 | |aVirtual screening |
|---|
| 653 | |aAlzheimer's disease |
|---|
| 653 | |aEnzym y—secretase |
|---|
| 653 | |aGSMs |
|---|
| 653 | |aHoạt hóa enzym y—secretase |
|---|
| 700 | |aTrần, Thái Sơn |
|---|
| 700 | |aVõ, Lưu Hoàng Tuấn |
|---|
| 700 | |aLê, Minh Trí |
|---|
| 700 | |aNguyễn, Hoàng Tiến |
|---|
| 773 | |tTạp chí Dược học |d2020|gTr. 19-24|i03 |
|---|
| 890 | |c1|a0|b0|d25 |
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