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  • Bài trích
  • Ký hiệu PL/XG: 615
    Nhan đề: Nghiên cứu xây dựng qui trình phân tích một số Glucocorticoid ngụy tạo trong mỹ phẩm điều trị mụn, làm trắng da bằng phương pháp LC-MS-MS /
DDC 615
Tác giả CN Nguyễn, Quốc Tuấn
Nhan đề Nghiên cứu xây dựng qui trình phân tích một số Glucocorticoid ngụy tạo trong mỹ phẩm điều trị mụn, làm trắng da bằng phương pháp LC-MS-MS / Nguyễn Quốc Tuấn, Đỗ Châu Minh Vĩnh Thọ
Tóm tắt A reversed-phase LC-MS-MS method was developed for simultaneous determination of dexamethasone acetate (DXA), betamethasone (BM), prednisolone (PR), triamcinolone acetonide (TCA) in cosmetics treating acne or for skin whitening. The procdure was optimized as: Column - Phenomenex Gemini C-18 (150 x 4.6 mm, 5μm); Mobile phase - ACN-H2O in gradient mode; Sample injection volume - 5μl; Electrospray ionnization source was operated in positive mode and multi reaction monitoring (MRM) mode using the transition of m/z 435.20 " 397.25; m/z 393.11 " 147.06; m/z 361.22 "147.13; m/z 345.20 "397.25 and m/z 375.18 "161.17 were used to quantify DXA, BM, PR, TCA and methyl prednisolone (IS), respectively. Validated in accordance to AOAC guidelines, the method proved to meet the requirements: Wide linearity range (20-750ppb) and high correlation coefficient (R2> 0.9982), very good accuracy (recovery rate - 90.2– 112.2%) and intra-day precision (RSD < 6.5%), typical LOD, LOQ values (0.1-0.3ppb and 0.33-9.9ppb for each of all four glucocorticoids). On practical application, 20 commercial cosmetic products for acnes and whitening skin Tra Vinh province was controlled to determine these four corticoids. Of these cosmetics, 35% were detected to be adulterated with corticosteroids.
Thuật ngữ chủ đề Nghiên cứu - Kỹ thuật --Việt Nam
Từ khóa tự do Glucocorticoid
Từ khóa tự do LC-MS-MS
Tác giả(bs) CN Đỗ, Châu Minh Vĩnh Thọ
Nguồn trích Tạp chí Dược học 2018tr. 67-72 Số: 02
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0029
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005201912131113
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039|y20191213111352|zthienvan
082 |a615
100 |aNguyễn, Quốc Tuấn
245 |aNghiên cứu xây dựng qui trình phân tích một số Glucocorticoid ngụy tạo trong mỹ phẩm điều trị mụn, làm trắng da bằng phương pháp LC-MS-MS / |cNguyễn Quốc Tuấn, Đỗ Châu Minh Vĩnh Thọ
520 |aA reversed-phase LC-MS-MS method was developed for simultaneous determination of dexamethasone acetate (DXA), betamethasone (BM), prednisolone (PR), triamcinolone acetonide (TCA) in cosmetics treating acne or for skin whitening. The procdure was optimized as: Column - Phenomenex Gemini C-18 (150 x 4.6 mm, 5μm); Mobile phase - ACN-H2O in gradient mode; Sample injection volume - 5μl; Electrospray ionnization source was operated in positive mode and multi reaction monitoring (MRM) mode using the transition of m/z 435.20 " 397.25; m/z 393.11 " 147.06; m/z 361.22 "147.13; m/z 345.20 "397.25 and m/z 375.18 "161.17 were used to quantify DXA, BM, PR, TCA and methyl prednisolone (IS), respectively. Validated in accordance to AOAC guidelines, the method proved to meet the requirements: Wide linearity range (20-750ppb) and high correlation coefficient (R2> 0.9982), very good accuracy (recovery rate - 90.2– 112.2%) and intra-day precision (RSD < 6.5%), typical LOD, LOQ values (0.1-0.3ppb and 0.33-9.9ppb for each of all four glucocorticoids). On practical application, 20 commercial cosmetic products for acnes and whitening skin Tra Vinh province was controlled to determine these four corticoids. Of these cosmetics, 35% were detected to be adulterated with corticosteroids.
650 |aNghiên cứu - Kỹ thuật |zViệt Nam
653 |aGlucocorticoid
653 |aLC-MS-MS
700 |aĐỗ, Châu Minh Vĩnh Thọ
773 |tTạp chí Dược học |d2018|gtr. 67-72|i02
890|c1|a0|b0|d3
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