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Flow chemistry for the synthesis of Heterocycles / Upendra K. Sharma, Erik V. Van der Eycken (editor)
Switzerland : Springer, 2018
vii, 397 pages. : illustrations ; 25 cm.
Ký hiệu phân loại (DDC): 547
This volume provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability. In recent times, flow chemistry has heralded a paradigm shift in organic synthesis as it offers several unique advantages over conventional methods like drastic acceleration of sluggish transformations, enhanced yields, cleaner reactions etc and is gradually gaining a lot of attention among organic chemist worldwide. Given the importance of heterocycles in natural products, medicinal chemistry and pharmaceuticals, this is a well warranted volume and complements the previous volume of Topics in Organometallic Chemistry ‘Organometallic Flow Chemistry’. This volume offers a versatile overview of the topic, besides discussing the recent progress in the flourishing area of flow chemistry in relevance to heterocyclic chemistry; it will also help researchers to better understand the chemistry behind these reactions. This in turn provides a platform for future innovations towards the designing of novel transformations under continuous flow. Thus, this volume will appeal to both the novices in this field as well as to experts in academia and industry.
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Topics in Medicinal Chemistry / Peter R. Bernstein, Amanda L. Garner, Gunda I. Georg, Stefan A. Laufer, John A. Lowe, Nicholas A. Meanwell, A. K. Saxena, Claudiu T. Supuran, Ao Zhang, Nuska Tschammer, Sally-Ann Poulsen
Switzerland : Springer, 2022
tr. ; cm.
Ký hiệu phân loại (DDC): 615
Topics in Medicinal Chemistry (TMC) covers all relevant aspects of medicinal chemistry research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. To fulfil this need, TMC is intended for researchers and experts working in academia and in the pharmaceutical industry, and also for graduates that look for a carefully selected collection of high quality review articles on their respective field of expertise.
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